3 Result(s)
within
Mei-ling Han
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are often the only therapeutic opt...
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Article
Open AccessA polytherapy based approach to combat antimicrobial resistance using cubosomes
A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-negative ‘superbugs’ has increased interest in nano therapies to treat antibiotic resistance. As cubosomes and polymyxins d...
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Article
Open AccessGlobal metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxin-susceptible and ...
