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Article
Open AccessA synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are often the only therapeutic opt...
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Chapter
History, Chemistry and Antibacterial Spectrum
Polymyxins are naturally occurring cyclic lipopeptides that were discovered more than 60 years ago. They have a narrow antibacterial spectrum, which is mainly against Gram-negative pathogens. The dry antibioti...
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Chapter
Discovery of Novel Polymyxin-Like Antibiotics
The antimicrobial lipopeptides polymyxin B and colistin (polymyxin E) are used as a ‘last-line’ therapy for infections caused by multidrug-resistant (MDR) Gram-negative pathogens. However, their effective use ...
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Article
A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
Polymyxin B and colistin were examined for their ability to inhibit the type II NADH-quinone oxidoreductases (NDH-2) of three species of Gram-negative bacteria. Polymyxin B and colistin inhibited the NDH-2 act...
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Article
Synthesis of “Difficult” Fluorescence Quenched Substrates of Granzyme C
The synthesis of fluorescence quenched peptide substrates of granzyme C is presented. These peptides which incorporate some unusual amino acids and have “difficult sequence” elements, in some cases could not b...
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Article
Mechanisms for the selective gas-phase fragmentation reactions of methionine side chain fixed charge sulfonium ion containing peptides
To enable the development of improved tandem mass spectrometry based methods for selective proteome analysis, the mechanisms, product ion structures, and other factors influencing the gas-phase fragmentation r...
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Article
Selective identification and quantitative analysis of methionine containing peptides by charge derivatization and tandem mass spectrometry
To enable the development of a tandem mass spectrometry (MS/MS) based methodology for selective protein identification and differential quantitative analysis, a novel derivatization strategy is proposed, based...
