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Article
The evolutionary innovation of root suberin lamellae contributed to the rise of seed plants
Seed plants overtook ferns to become the dominant plant group during the late Carboniferous, a period in which the climate became colder and dryer1,2. However, the specific innovations driving the success of seed...
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Article
A new family of proteins is required for tethering of Casparian strip membrane domain and nutrient homoeostasis in rice
Cell–cell junctions are essential for multicellular organisms to maintain nutrient homoeostasis. A plant-type tight junction, the Casparian strip (CS)–Casparian strip membrane domain (CSD) that seals the parac...
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Article
Open AccessA synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are often the only therapeutic opt...
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Article
Open AccessA polytherapy based approach to combat antimicrobial resistance using cubosomes
A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-negative ‘superbugs’ has increased interest in nano therapies to treat antibiotic resistance. As cubosomes and polymyxins d...
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Article
Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation
Sensing of microbes activates the innate immune system, depending on functional mitochondria. However, pathogenic bacteria inhibit mitochondrial activity by delivering toxins via outer membrane vesicles (OMVs)...
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Article
A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial–mesenchymal transition
Cathepsin L (CTSL), a cysteine protease, is closely related to tumor occurrence, development, and metastasis, and possibly regulates cancer cell resistance to chemotherapy. miRNAs, especially the miR-200 famil...
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Article
Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells
Cathepsin L (CTSL), a lysosomal acid cysteine protease, is known to play important roles in tumor metastasis and chemotherapy resistance. In this study we investigated the molecular mechanisms underlying the r...
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Article
Open AccessTaxonomy and phylogeny of the brown-rot fungi: Fomitopsis and its related genera
Taxonomic and phylogenetic studies on the brown-rot fungi, Fomitopsis and its related genera, are carried out. On the basis of morphological characters and phylogenetic evidence of DNA sequences of multiple loci ...
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Article
Open AccessGlobal metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxin-susceptible and ...
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Article
Morphology and molecular phylogeny for two new species of Fomitopsis (Basidiomycota) from South China
Two new species of Fomitopsis from South China are described based on morphological characters and molecular evidence. Fomitopsis cystidiata sp. nov. is unique due to its annual and conchoidal to flabelliform bas...
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Article
Two new Fomitopsis species from southern China based on morphological and molecular characters
Fomitopsis cana sp. nov. and F. subtropica sp. nov. are described from southern China based on morphological and molecular characters. Both species have annual, effused-reflexed basidiomata with ...
