Skip to main content

4 Result(s)

within Matthew J. Delano Remove this filter

and

  1. No Access

    Article

    Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

    Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell death protein-1 (PD-1)-mediated T-cell function impairment. ...

    Richard S. Hotchkiss, Elizabeth Colston, Sachin Yende… in Intensive Care Medicine (2019)

  2. No Access

    Article

    Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia

    Previously, we reported that electroporation-mediated (EP) delivery of the FER gene improved survival in a combined trauma-pneumonia model. The mechanism of this protective effect is unknown. In this paper, we...

    Vladislav Dolgachev, Sreehari Panicker, Sanjay Balijepalli… in Gene Therapy (2018)

  3. Article

    CXCR3 blockade: a novel anti-sepsis approach?

    Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and infl...

    Matthew J Delano, Lyle L Moldawer in Critical Care (2012)

    Download PDF (186 KB) View Article

  4. Article

    Open Access

    A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma

    Myeloid-derived suppressor cells (MDSCs) are a heterogenous population of immature myeloid cells whose numbers dramatically increase in chronic and acute inflammatory diseases, including cancer, autoimmune dis...

    Alex G. Cuenca, Matthew J. Delano, Kindra M. Kelly-Scumpia… in Molecular Medicine (2011)

    Download PDF (2051 KB) View Article