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Long COVID and kidney disease
Kidney involvement is common in patients with acute SARS-CoV-2 infection, and subclinical inflammation and injury may persist for many months, resulting in a progressive decline in kidney function that leads t...
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Open AccessPlasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)
Pneumonia is the most common cause of mortality from infectious diseases, the second leading cause of nosocomial infection, and the leading cause of mortality among hospitalized adults. To improve clinical man...
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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab
Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell death protein-1 (PD-1)-mediated T-cell function impairment. ...
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Open AccessPrecision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness
All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critic...
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Open AccessPlasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic t...
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Open AccessUnderstanding the complex host response in sepsis: is diabetes the key?
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Open AccessUnderstanding skeletal muscle wasting in critically ill patients
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Open AccessBenefits of lung-protective ventilation: looking beyond the ICU
No abstract.
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Open AccessEffects of intra-abdominal sepsis on atherosclerosis in mice
Sepsis and other infections are associated with late cardiovascular events. Although persistent inflammation is implicated, a causal relationship has not been established. We tested whether sepsis causes vascu...
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Blood transfusion for upper gastrointestinal bleeding: is less more again?
The hemoglobin threshold for transfusion of red blood cells in patients withacute gastrointestinal (GI) bleeding is controversial. We compared theefficacy and safety of a restrictive transfusion strategy with ...
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Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study
To determine the global metabolomic profile as measured in circulating plasma from surviving and non-surviving patients with community-acquired pneumonia (CAP) and sepsis.
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A touch of cooling may help
Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N, Dellamonica J, Bouadma L, Cook F, Beji O, Brun-Buisson C, Lemaire F, Brochard L: Multicenter randomized controlled clinical trial of fever contr...
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Towards personalized medicine in sepsis: Quest for Shangri-La?
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS: Immunosuppression in patients who die of sepsis and...
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Weighing risks and benefits of stress ulcer prophylaxis in critically ill patients
Marik PE, Tajender Vasu T, Hirani A, Pachinburavan M: Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis. Critical Care Med 2010, 38:11.
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Protocol-directed care in the ICU: making a future generation of intensivists less knowledgeable?
Prasad M, Holmboe ES, Lipner RS, Hess BJ, Christie JD, Bellamy SL, Rubenfeld GD, Kahn JM. Clinical Protocols and Trainee Knowledge About Mechanical Ventilation. JAMA. 2011; 306(9):935-941. PubMed PMID: 2190013...
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Glucocorticoid therapy for trauma - ready for prime time?
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Revisiting Mars and Venus: understanding gender differences in critical illness
Understanding the nature and biological basis of gender-determined differences in risk of and outcome from infection might identify new therapeutic targets, allow more individualised treatment, and facilitate ...
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Pushing the envelope to reduce sedation in critically ill patients
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Comparing different thrombolytic dosing regimens for treatment of acute pulmonary embolism
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Epinephrine: Is it really the black sheep of vasoactive agents?