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Article
Open AccessPreserved neural dynamics across animals performing similar behaviour
Animals of the same species exhibit similar behaviours that are advantageously adapted to their body and environment. These behaviours are shaped at the species level by selection pressures over evolutionary t...
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Article
Open AccessMesolimbic dopamine adapts the rate of learning from action
Recent success in training artificial agents and robots derives from a combination of direct learning of behavioural policies and indirect learning through value functions1–3. Policy learning and value learning u...
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Article
Open AccessHippocampal representations of foraging trajectories depend upon spatial context
Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and...
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Protocol
In Vivo Optogenetics with Stimulus Calibration
Optogenetic reagents allow for depolarization and hyperpolarization of cells with light. This provides unprecedented spatial and temporal resolution to the control of neuronal activity both in vitro and in viv...
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Article
Publisher Correction: A repeated molecular architecture across thalamic pathways
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
A repeated molecular architecture across thalamic pathways
The thalamus is the central communication hub of the forebrain and provides the cerebral cortex with inputs from sensory organs, subcortical systems and the cortex itself. Multiple thalamic regions send conver...
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Article
The timing of action determines reward prediction signals in identified midbrain dopamine neurons
Animals adapt their behavior in response to informative sensory cues using multiple brain circuits. The activity of midbrain dopaminergic neurons is thought to convey a critical teaching signal: reward-predict...
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Article
Open AccessDesensitized D2 autoreceptors are resistant to trafficking
Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons. This study used tagged D2 receptor...
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Article
Opponent and bidirectional control of movement velocity in the basal ganglia
Activity in the direct and indirect basal ganglia pathways can bidirectionally control the speed of movements that underlie reward-seeking actions in mice without affecting motivation.
