-
Article
The next generation of therapeutics for chronic kidney disease
Approximately 20 million people in the United States are currently affected by CKD, with half a million of these presenting with the most severe form: end-stag...
-
Article
Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells
High salt diet induces renal medullary cyclooxygenase 2 (COX2) expression. Selective blockade of renal medullary COX2 activity in rats causes salt-sensitive hypertension, suggesting a role for renal medullary ...
-
Article
Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1
To examine the contribution of vascular membrane-associated prostaglandin E2 synthase-1 (mPGES-1) to acute blood pressure homeostasis.
-
Protocol
Measurement of Glomerular Filtration Rate in Conscious Mice
Glomerular filtration rate (GFR) is an important index of renal function and routinely used in patient care and basic research to evaluate progression of renal diseases or test the efficacy of novel therapeuti...
-
Reference Work Entry In depth
Prostanoids
-
Article
Examining diabetic nephropathy through the lens of mouse genetics
Although diabetic nephropathy occurs in only a minority of patients with diabetes, it is the major cause of end-stage renal disease in the United States. Hyperglycemia and hypertension are important factors pr...
-
Article
Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
Thiazolidinediones (TZDs) are widely used to treat type 2 diabetes mellitus; however, their use is complicated by systemic fluid retention. Along the nephron, the pharmacological target of TZDs, peroxisome pro...
-
Article
Open AccessCloning and expression of the rabbit prostaglandin EP2 receptor
Prostaglandin E2 (PGE2) has multiple physiologic roles mediated by G protein coupled receptors designated E-prostanoid, or "EP" receptors. Evidence supports an important role for the EP2 receptor in regulating fe...
-
Chapter
Targeted gene disruption of the prostaglandin e2 ep2 receptor
Prostaglandins comprise a diverse family of autacoids derived from cyclooxygenase (COX) metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-active prostaglandin (PG) metab...
-
Article
Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
Prostaglandins (PGs) are ubiquitous lipid mediators derived from cyclooxygenase metabolism of arachidonic acid that exert a broad range of physiologic activities, including modulation of inflammation, ovulation1,
-
Chapter
Structure and Localization of the Rabbit Prostaglandin EP3 Receptor
Prostaglandin E2 (PGE2) is a potent modulator of a wide variety of physiological responses including inflammation (1), gastric acid secretion (2), vascular tone (3), lipolysis (4) and water and ion transport (5)....
