11 Result(s)
within
Matthew D Hall
Life Sciences
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Article
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combi...
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Article
Surrounded by ligands: the reactivity of cisplatin in cell culture medium
The reactivity of platinum-containing drugs such as cisplatin, carboplatin, and oxaliplatin is essential for its mechanism of action as an anticancer agent. This inherent reactivity means that molecules in too...
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Article
Effect of habitat permanence on life-history: extending the Daphnia model into new climate spaces
We use an Australian freshwater invertebrate species, Daphnia carinata, to assess whether variation in habitat permanence influences life-history traits in subpopulations. Using a life table experiment, we measur...
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Article
Open AccessThe trans-generational impact of population density signals on host-parasite interactions
The density of a host population is a key parameter underlying disease transmission, but it also has implications for the expression of disease through its effect on host physiology. In response to higher dens...
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Protocol
In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood–Brain Barrier
We provide a detailed protocol for imaging ATP-binding cassette subfamily G member 2 (ABCG2) function at the blood–brain barrier (BBB) of transgenic mice. d-Luciferin is specifically transported by ABCG2 found on...
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Chapter
The ABCG2 Multidrug Transporter
ABCG2 is an ATP-binding cassette (ABC) half-transporter localized to the cell membrane and important in normal physiology, in normal tissue protection including in the maternal-fetal barrier and the blood brai...
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Article
Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs
The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence have been extensively studied in the laboratory setting, sometimes by generating fluorophore-ta...
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Article
Open AccessAn SNP-based second-generation genetic map of Daphnia magna and its application to QTL analysis of phenotypic traits
Although Daphnia is increasingly recognized as a model for ecological genomics and biomedical research, there is, as of yet, no high-resolution genetic map for the genus. Such a map would provide an important too...
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Article
Open AccessThe genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on ...
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Article
Interactions between environmental stressors: the influence of salinity on host–parasite interactions between Daphnia magna and Pasteuria ramosa
Interactions between environmental stressors play an important role in sha** the health of an organism. This is particularly true in terms of the prevalence and severity of infectious disease, as stressors i...
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Article
The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells
The cellular distribution of platinum in A2780 ovarian cancer cells treated with cisplatin and platinum(IV) complexes with a range of reduction potentials has been examined using elemental analysis (synchrotro...
