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  1. No Access

    Chapter

    Synchrotron Radiation X-Ray Spectroscopy for Investigations of Intracellular Metallointercalators: X-Ray Fluorescence Imaging and X-Ray Absorption Spectroscopy

    In an effort to determine the therapeutic feasibility of DNA metallointercalators as potential anticancer drugs it is important to confirm that they are capable of targeting DNA in cancer cells or tumours – as...

    Carolyn T. Dillon in Metallointercalators (2011)

  2. No Access

    Article

    Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper–indomethacin in rats

    To evaluate, for the first time, the efficacy of copper–indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT...

    Antonio M. Bonin, Jaime A. Yáñez, Chie Fukuda… in Cancer Chemotherapy and Pharmacology (2010)

  3. No Access

    Article

    Intracellular map** of the distribution of metals derived from the antitumor metallocenes

    The intracellular distribution of transition metals in V79 Chinese hamster lung cells treated with subtoxic doses of the organometallic anticancer complexes Cp2MCl2, where Cp is η 5 -cyclopentadienyl and M is...

    Jenny B. Waern, Hugh H. Harris, Barry Lai… in JBIC Journal of Biological Inorganic Chemi… (2005)

  4. No Access

    Article

    Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques

    Chromium(VI) is a human carcinogen, primarily affecting the respiratory tract probably via active transport into cells, followed by the reduction to Cr(III) with the formation of DNA-damaging intermediates. Di...

    Hugh H. Harris, Aviva Levina… in JBIC Journal of Biological Inorganic Chemi… (2005)

  5. No Access

    Article

    The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells

    The cellular distribution of platinum in A2780 ovarian cancer cells treated with cisplatin and platinum(IV) complexes with a range of reduction potentials has been examined using elemental analysis (synchrotro...

    Matthew D. Hall, Carolyn T. Dillon… in JBIC Journal of Biological Inorganic Chemi… (2003)

  6. No Access

    Article

    Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular map** of the biotransformation products of a chromium carcinogen

    The uptake of carcinogenic and mutagenic Cr compounds and the intracellular distribution of their biotransformation products in V79 Chinese hamster lung cells were studied by synchrotron-radiation-induced X-r...

    Carolyn T. Dillon, Peter A. Lay… in JBIC Journal of Biological Inorganic Chemi… (2002)