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Article
Open AccessO-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhi...
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Article
Comparative evaluation of outcomes amongst different radiosurgery management paradigms for patients with large brain metastasis
This study compares four management paradigms for large brain metastasis (LMB): fractionated SRS (FSRS), staged SRS (SSRS), resection and postoperative-FSRS (postop-FSRS) or preoperative-SRS (preop-SRS).
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Article
Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and industry, culminating in several therapeutics being discovered, appr...
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Article
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combi...
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Article
Surrounded by ligands: the reactivity of cisplatin in cell culture medium
The reactivity of platinum-containing drugs such as cisplatin, carboplatin, and oxaliplatin is essential for its mechanism of action as an anticancer agent. This inherent reactivity means that molecules in too...
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Article
Open AccessPreclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...
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Article
Open AccessEvaluation of the impact of pre-operative stereotactic radiotherapy on the acute changes in histopathologic and immune marker profiles of brain metastases
The unique acute effects of the large fractional doses that characterize stereotactic radiosurgery (SRS) or radiotherapy (SRT), specifically in terms of antitumor immune cellular processes, vascular damage, tu...
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Article
Open AccessHospitalization rates from radiotherapy complications in the United States
Hospitalizations due to radiotherapy (RT) complications result in significant healthcare expenditures and adversely affect the quality of life of cancer patients. Using a nationally representative dataset, the...
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Article
Open AccessCharacterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter
Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2). However, little information is available regarding A...
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Article
Open AccessFactors associated with unplanned readmissions and costs following resection of brain metastases in the United States
The purpose of this study was to critically analyze the risk of unplanned readmission following resection of brain metastasis and to identify key risk factors to allow for early intervention strategies in high...
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Article
Open AccessSystematic review and meta-analysis of lung cancer brain metastasis and primary tumor receptor expression discordance
Treatment paradigms for metastatic non-small cell lung cancer are increasingly based on biomarker-driven therapies, with the most common alteration being mutation in the epidermal growth factor receptor (EGFR)...
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Article
Open AccessDevelopment of therapies for rare genetic disorders of GPX4: roadmap and opportunities
Extremely rare progressive diseases like Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD) can be neonatally lethal and therefore go undiagnosed or are difficult to treat. Recent sequencing efforts have li...
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Article
Effect of habitat permanence on life-history: extending the Daphnia model into new climate spaces
We use an Australian freshwater invertebrate species, Daphnia carinata, to assess whether variation in habitat permanence influences life-history traits in subpopulations. Using a life table experiment, we measur...
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Article
Serologic Cross-Reactivity of SARS-CoV-2 with Endemic and Seasonal Betacoronaviruses
In order to properly understand the spread of SARS-CoV-2 infection and development of humoral immunity, researchers have evaluated the presence of serum antibodies of people worldwide experiencing the pandemic...
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Article
Open AccessHospitalization rates for complications due to systemic therapy in the United States
The aim of this study was to estimate the trends and burdens associated with systemic therapy-related hospitalizations, using nationally representative data. National Inpatient Sample data from 2005 to 2016 wa...
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Article
Open AccessStandardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling
The extent of SARS-CoV-2 infection throughout the United States population is currently unknown. High quality serology is key to avoiding medically costly diagnostic errors, as well as to assuring properly inf...
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Article
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition
Brain tumors are the most common solid tumors of childhood, and the genetic drivers and optimal therapeutic strategies for many of the different subtypes remain unknown. Here, we identify that bithalamic gliom...
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Article
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
H3 K27M-mutant diffuse midline glioma is a fatal malignancy with no proven medical therapies. The entity predominantly occurs in children and young adults. ONC201 is a small molecule selective antagonist of do...
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Article
Discovery of novel inhibitors of human galactokinase by virtual screening
Classic Galactosemia is a potentially lethal autosomal recessive metabolic disorder caused by deficient galactose-1-phosphate uridyltransferase (GALT) that results in the buildup of galactose-1-phosphate (gal-...
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Ewing Sarcoma and Osteosarcoma
Pediatric bone tumors are treated with multiagent systemic chemotherapy combined with surgery and/or radiation therapy for local therapy.
