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Open AccessEpigenetic signals associated with delirium replicated across four independent cohorts
Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknow...
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Article
Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography
Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present t...
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Article
Amygdala lesions are associated with improved mood after epilepsy surgery
Neuroimaging studies in healthy and clinical populations strongly associate the amygdala with emotion, especially negative emotions. The consequences of surgical resection of the amygdala on mood are not well ...
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Article
Open AccessDNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium
The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epile...
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Open AccessGenome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but access to brain tissues is essentially limited to postmortem samples. The use of surrogate tissues has become common ...
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Open AccessNon-linear dependency between spiking response and gamma-band power of local field potentials in the human auditory cortex
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Direct Recordings from the Auditory Cortex in a Cochlear Implant User
Electrical stimulation of the auditory nerve with a cochlear implant (CI) is the method of choice for treatment of severe-to-profound hearing loss. Understanding how the human auditory cortex responds to CI st...
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Invasive Research Methods
Auditory cortex, in the classic sense of the term, is taken to be the cluster of anatomically and physiologically distinct areas of temporal neocortex that are uniquely and reciprocally connected with one anot...
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Article
Seizure termination by acidosis depends on ASIC1a
Acidosis can stop seizures, but it is unclear how it does this. This study demonstrates that the acid-sensing channel ASIC1a is required for either spontaneous or CO2-induced termination of convulsant-induced sei...
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Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex
Both lesion and functional imaging studies in humans1,2, as well as neurophysiological studies in nonhuman primates3, demonstrate the importance of the prefrontal cortex in representing the emotional value of sen...
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Physiologic effects of nucleus basalis magnocellularis stimulation on rat barrel cortex neurons
Cholinergic neurons in the nucleus basalis magnocellularis (NBM) project to the cerebral cortex and are thought to play an important role in learning and memory, and other cognitive functions. In the present s...