8 Result(s)
within
Masayuki Yamato
Regenerative Medicine/Tissue Engineering
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Article
Open AccessPolydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis
Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of autologous chondrocyte cell-sheets along with open-wedge high tibial...
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Article
Open AccessBio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection
Lung air leaks (LALs) due to visceral pleura injury during surgery are a difficult-to-avoid complication in thoracic surgery (TS). Reliable LAL closure is an important patient management issue after TS. We dem...
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Article
Open AccessCombined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis
Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro a...
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Chapter
Design of Temperature-Responsive Cell Culture Surfaces for Cell Sheet-Based Regenerative Therapy and 3D Tissue Fabrication
This chapter describes the concept of “cell sheet engineering” for the creation of transplantable cellular tissues and organs. In contrast to scaffold-based tissue engineering, cell sheet engineering facilitat...
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Article
Open AccessBio-artificial pleura using an autologous dermal fibroblast sheet
Air leaks (ALs) are observed after pulmonary resections, and without proper treatment, can produce severe complications. AL prevention is a critical objective for managing patients after pulmonary resection. T...
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Article
Open AccessMiddle ear mucosal regeneration by tissue-engineered cell sheet transplantation
The recurrence of cholesteatoma after surgical treatment often occurs as a result of poor mucosal regeneration in the middle ear cavity and mastoid cavity and changes, such as granulation tissue formation, whi...
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Protocol
Cell Sheet Technology for Cardiac Tissue Engineering
In this chapter, we describe the methods for the fabrication and transfer/transplantation of 3D tissues by using cell sheet technology for cardiac tissue regeneration. A temperature-responsive culture surface ...
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Article
Successive grafting of PHEMA and PIPAAm onto cell culture surface enables rapid cell sheet recovery
Fabrication of functional tissue constructs from designed three-dimensional structure of cells using layered method of cultured cell sheets could prove to be an attractive approach to tissue engineering. Rapid...
