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  1. Article

    Open Access

    Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

    Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological proc...

    Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi in Nature Communications (2021)

  2. Article

    Open Access

    Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

    Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in the gut microbiome have been implicated in th...

    Ryo Aoki, Masayoshi Onuki, Koya Hattori, Masato Ito, Takahiro Yamada in Microbiome (2021)