-
Article
Brazilian propolis (AF-08) inhibits collagen-induced platelet aggregation without affecting blood coagulation
Brazilian propolis (AF-08) is a dietary supplement containing a variety of flavonoids. It is used worldwide as a folk medicine. Flavonoids and a diet of fruits and vegetables containing them have been shown to...
-
Article
Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice
Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and t...
-
Article
Naringenin interferes with the anti-diabetic actions of pioglitazone via pharmacodynamic interactions
Pioglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) full agonist and useful for the treatment of type 2 diabetes mellitus. Naringenin is a citrus flavonoid with anti-inflammatory actions...
-
Article
Inhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells
As obesity is a global health concern the demand for anti-obesity drugs is high. In this study, we investigated the anti-obesity effect of the dried branches and leaves of murta (Myrceugenia euosma Legrand, Myrta...
-
Article
Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo
We previously showed that (5S)-5-hydroxy-7-(4-hydroxyphenyl)-1-phenylhept-3-one (AO-0011) and (5S)-5-methoxy-1,7-diphenylhept-3-one (AO-0016) isolated from Alpinia officinarum exhibited stronger anti-influenza vi...
-
Article
Antiviral activities of diarylheptanoids against influenza virus in vitro
The anti-influenza A/PR/8/34 (H1N1) virus activities of ten diarylheptanoids isolated from Alpinia officinarum were examined using the MTT method. The 50% inhibitory concentration of each diarylheptanoid examined...
-
Article
Failure of treatment with interleukin-2 receptor-specific monoclonal antibody in acute coxsackievirus B3 myocarditis in mice
T cell activation is assumed to play a crucial role in many viral infections. An important marker for the activation of T cells is the interleukin-2 receptor (IL-2R); resting T lymphocytes do not bear detectab...
-
Article
Effects of levamisole, an immunomodulator, upon murine encephalomyocarditis virus myocarditis
To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalomyocarditis virus. Levamisole (2.5mg/kg/per day) was administere...
-
Article
The effects of lobenzarit disodium, a novel immunomodulator, upon murine coxsackievirus B3 myocarditis
The aim of this study is to test the therapeutic efficacy of immunomodulation with lobenzarit disodium (CCA) upon coxsackievirus B3 (CB3) myocarditis. Two-week-old C3H/He mice were inoculated with 103 plaque-form...
-
Article
Augmentation of murine lymphokine-activated killer cell cytotoxicity by β-cyclodextrin-benzaldehyde
We investigated the effect ofβ-cyclodextrin-benzaldehyde (CDBA) on lymphokine-activated killer (LAK) cell activity of spleen cells from normal or RCT(+)H-2+-sarcoma-bearing C3H/He mice. CDBA augmented the inducti...
