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Article
Open AccessDesigning and computational analyzing of chimeric long-lasting GLP-1 receptor agonists for type 2 diabetes
Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1–2 min) of ...
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Article
Open AccessThe lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles
The high cost of fermentation, purification, cold storage and transportation, short shelf life, and sterile delivery methods of biopharmaceuticals, is a matter for producers and consumers as well. Since the FD...
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Article
Open AccessThe production of the first functional antibody mimetic in higher plants: the chloroplast makes the DARPin G3 for HER2 imaging in oncology
Designed mimetic molecules are attractive tools in biopharmaceuticals and synthetic biology. They require mass and functional production for the assessment of upcoming challenges in the near future. The DARPin...
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Article
Efficient use of the PMI/mannose selection system in Agrobacterium-mediated transformation of tobacco (Nicotiana tabacum)
A safe and environment friendly selectable marker system using phosphomannose isomerase (pmi) gene was employed for Agrobacterium tumefaciens mediated transformation of tobacco (Nicotinia tabacum L.). Sensitivity...
