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Article

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1. Here we show that the E3 ubiquitin ligase CHIP controls NOXA stability after D...

Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa… in Cell Death & Disease (2020)