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Article
Open AccessStool energy density is positively correlated to intestinal transit time and related to microbial enterotypes
It has been hypothesised that the gut microbiota causally affects obesity via its capacity to extract energy from the diet. Yet, evidence elucidating the role of particular human microbial community structures...
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Article
Open AccessBifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and the gut microbiota can impact host physiology in various ways, such as through the production...
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Article
Open AccessData integration for prediction of weight loss in randomized controlled dietary trials
Diet is an important component in weight management strategies, but heterogeneous responses to the same diet make it difficult to foresee individual weight-loss outcomes. Omics-based technologies now allow for...
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Article
Open AccessHuman microbiota-transplanted C57BL/6 mice and offspring display reduced establishment of key bacteria and reduced immune stimulation compared to mouse microbiota-transplantation
Transplantation of germ-free (GF) mice with microbiota from mice or humans stimulates the intestinal immune system in disparate ways. We transplanted a human microbiota into GF C57BL/6 mice and a murine C57BL/...
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Article
Open AccessA low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adul...
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Article
Open AccessAberrant intestinal microbiota in individuals with prediabetes
Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with ...
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Article
Open AccessMicrobiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime
Germ-free rodents colonized with microbiotas of interest are used for host-microbiota investigations and for testing microbiota-targeted therapeutic candidates. Traditionally, isolators are used for housing su...
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Article
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently b...
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Article
Open AccessTransfer of gut microbiota from lean and obese mice to antibiotic-treated mice
Transferring gut microbiota from one individual to another may enable researchers to “humanize” the gut of animal models and transfer phenotypes between species. To date, most studies of gut microbiota transfe...
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Article
Open AccessNature of bacterial colonization influences transcription of mucin genes in mice during the first week of life
Postnatal regulation of the small intestinal mucus layer is potentially important in the development of adult gut functionality. We hypothesized that the nature of bacterial colonization affects mucus gene reg...
