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Article
Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3
Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human uroc...
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Article
Suppression of the proliferation of human U-87 MG glioblastoma cells by new antagonists of growth hormone-releasing hormone in vivo and in vitro
Five-year survival of patients afflicted with glioblastoma multiforme (GBM) is rare, making this cancer one of the most feared malignancies. Previously, we reported that growth hormone-releasing hormone (GHRH)...
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Article
Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ-specific changes in the expression of angiogenesis
This study seeks to determine if growth hormone-releasing hormone (GHRH) antagonist, JMR-132, increases survival when given before whole body radiation.
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Article
Open AccessAntiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway
Antagonists of growth hormone-releasing hormone (GHRH) are being developed for the treatment of various human cancers.
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Article
Open AccessThe Immunohistochemical Expression of Growth Hormone-Releasing Hormone Receptor Splice Variant 1 Is a Favorable Prognostic Marker in Colorectal Cancer
Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence dem...
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Article
Aged synthetic human amyloid β-peptide 1-42 and related fragments induce direct acetylcholine release from rat basal forebrain tissue slices
The direct effects of synthetic human amyloid β-peptide 1–42 (Aβ1–42), scrambled Aβ1–42 (MOD1 and MOD2), and related fragments (Aβ31–35, Aβ34–39, and Aβ17–21), either freshly dissolved (non-aged) or aged for 2...