11 Result(s)
within
Marlies E van Wolfswinkel
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Article
Open AccessChanges in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers
Both in endemic countries and in imported malaria, changes in total and differential leukocyte count during Plasmodium falciparum infection have been described. To study the exact dynamics of differential leukocy...
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Article
Open AccessNeutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury
Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-base...
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Article
Open AccessAcute kidney injury in imported Plasmodium falciparum malaria
Acute kidney injury (AKI) is a known complication of malaria, and is reported to occur in up to 40 % of adult patients with a severe Plasmodium falciparum infection in endemic regions. To gain insight in the inci...
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Article
Open AccessSeverity of imported malaria: protective effect of taking malaria chemoprophylaxis
Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to incre...
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Open AccessPredictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria
Lymphocytopenia has frequently been described in patients with malaria, but studies on its association with disease severity have yielded conflicting results. The neutrophil/lymphocyte count ratio (NLCR) has b...
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Open AccessThe prognostic value of schizontaemia in imported Plasmodium falciparum malaria
In Plasmodium falciparum infection, peripheral parasite counts do not always correlate well with the sequestered parasite burden. As erythrocytes parasitized with mature trophozoites and schizonts have a high ten...
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Article
Open AccessHyponatraemia in imported malaria: the pathophysiological role of vasopressin
In the pathophysiology of hyponatraemia in malaria, the relative contribution of appropriate and inappropriate arginine vasopressin (AVP) release is unknown; the trigger for inappropriate AVP release is also u...
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Open AccessCopeptin does not accurately predict disease severity in imported malaria
Copeptin has recently been identified to be a stable surrogate marker for the unstable hormone arginine vasopressin (AVP). Copeptin has been shown to correlate with disease severity in leptospirosis and bacter...
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Open AccessA simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria
Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose.
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Article
Open AccessNeopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria
Most clinicians in developed, non-malaria endemic countries have limited or no experience in making clinical assessments of malaria disease severity and subsequent decisions regarding the need for parenteral t...
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Open AccessHyponatraemia in imported malaria is common and associated with disease severity
Hyponatraemia (serum sodium < 135 mmol/L) has long been recognized as a complication of malaria. However, few studies have been done in non-immune adult populations. It has not been investigated previously how...
