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  1. No Access

    Chapter

    New Animal Models for Hepatitis C

    The hepatotropic hepatitis C virus (HCV) belongs to the Flaviviridae family and chronically infects 130–150 million people worldwide. The severe consequences the virus has for liver health, especially if left unt...

    Markus von Schaewen, Jenna M. Gaska, Alexander Ploss in Hepatitis C Virus I (2016)

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    Protocol

    Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens

    Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying m...

    Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss in Mouse Models for Drug Discovery (2016)

  3. No Access

    Article

    AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

    The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor...

    Matthew R. Gardner, Lisa M. Kattenhorn, Hema R. Kondur, Markus von Schaewen… in Nature (2015)