91 Result(s)

Article

Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning

This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for the differential diagnosis of parkinsonism.

Yu Zhao, ** Wu, Jianjun Wu… in European Journal of Nuclear Medicine and M… (2022)

Article

Proof of concept of a multimodal intravital molecular imaging system for tumour transpathology investigation

Transpathology highlights the interpretation of the underlying physiology behind molecular imaging. However, it remains challenging due to the discrepancies between in vivo and in vitro measurements and diffic...

Zhen Liu, Tao Cheng, Stephan Düwel… in European Journal of Nuclear Medicine and M… (2022)

Article

Promise and challenges of clinical non-invasive T-cell tracking in the era of cancer immunotherapy

In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...

Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger… in EJNMMI Research (2022)

Article

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter… in EJNMMI Research (2021)

Article

Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted

Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren… in EJNMMI Research (2021)

Article

Correction to: Multi-scale imaging as an essential tool for precision medicine

An Erratum to this paper has been published: https://doi.org/10.1007/s00259-021-05396-y

Michael Phelps, Markus Schwaiger… in European Journal of Nuclear Medicine and M… (2021)

Article

Multi-scale imaging as an essential tool for precision medicine

Michael Phelps, Markus Schwaiger… in European Journal of Nuclear Medicine and M… (2021)

Article

Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow

Increased angiogenesis after myocardial infarction is considered an important favorable prognostic parameter. The αvβ3 integrin is a key mediator of cell-cell and cell-matrix interactions and an important mole...

Marcus R. Makowski, Christoph Rischpler… in European Journal of Nuclear Medicine and M… (2021)

Article

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions

To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography/magnetic resonance imaging ([¹⁸F]FDG-PET/MR) in predicting left ventricular (LV) wall motion re...

Teresa Vitadello, Karl P. Kunze… in European Journal of Nuclear Medicine and M… (2020)

Article

First In-Human Medical Imaging with a PASylated ⁸⁹Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer

PASylation® offers the ability to systematically tune and optimize the pharmacokinetics of protein tracers for molecular imaging. Here we report the first clinical translation of a PASylated Fab fragment (⁸⁹Zr∙Df...

Antonia Richter, Karina Knorr, Martin Schlapschy… in Nuclear Medicine and Molecular Imaging (2020)

Article

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the ...

Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer… in EJNMMI Research (2019)

Article

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ l...

Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer… in EJNMMI Research (2019)

Article

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using ⁶⁸Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD20...

Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster… in EJNMMI Research (2019)

Article

PET imaging of chemokine receptor CXCR4 in patients with primary and recurrent breast carcinoma

CXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis wa...

Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske… in EJNMMI Research (2018)

Article

Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expre...

Martina Wirtz, Alexander Schmidt, Margret Schottelius, Stephanie Robu… in EJNMMI Research (2018)

Article

Synthesis and preclinical evaluation of novel ¹⁸F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with ¹⁸F-DCFPyl and ¹⁸F-PSMA-1007

Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...

Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius… in EJNMMI Research (2018)

Article

Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis

Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer… in EJNMMI Research (2018)