29 Result(s)

Article

Positron detection for the intraoperative localisation of cancer deposits

The study investigated the feasibility of a positron-sensitive hand-held detector system for the intraoperative localisation of tumour deposits resulting from intravenous [¹⁸F]FDG administration.

Morand Piert, Maria Burian… in European Journal of Nuclear Medicine and M… (2007)

Article

Demonstration of metastatic tumour growth following vessel structures by PET/CT

Akram Al-Ibraheem, Ambros Beer, Andreas Buck… in European Journal of Nuclear Medicine and M… (2009)

Article

The risk of exaggerated risk aversion—a life and death struggle for molecular imaging

Bengt Långström, Anders Grahnen… in European Journal of Nuclear Medicine and M… (2009)

Article

Sensitivity of PET/MRI to detect recurrence of prostate cancer

Patricia Arce-Calisaya, Michael Souvatzoglou… in European Journal of Nuclear Medicine and M… (2013)

Article

Comparison of cyclic RGD peptides for α_vβ₃ integrin detection in a rat model of myocardial infarction

Expression of α_vβ₃ integrin is increased after myocardial infarction as part of the repair process. Increased expression of α_vβ₃ has been shown by molecular imaging with ¹⁸F-galacto-RGD in a rat model. The ⁶⁸Ga-l...

Iina Laitinen, Johannes Notni, Karolin Pohle, Martina Rudelius… in EJNMMI Research (2013)

Article

Synthesis and preclinical evaluation of DOTAGA-conjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer

Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously publis...

Martina Weineisen, Jakub Simecek, Margret Schottelius, Markus Schwaiger… in EJNMMI Research (2014)

Article

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice

Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different ¹⁸F-radiopharmaceuticals for clinical characterization of Alzheimer’s disease (AD)...

Behrooz H Yousefi, Boris von Reutern, Daniela Scherübl, André Manook… in EJNMMI Research (2015)

Article

Twins in spirit - episode I: comparative preclinical evaluation of [⁶⁸Ga]DOTATATE and [⁶⁸Ga]HA-DOTATATE

Recently, an intra-patient comparison demonstrated that the somatostatin (sst) ligand [⁶⁸Ga]HA-DOTATATE ([⁶⁸Ga]DOTA-3-iodo-Tyr³-octreotate) provides PET images comparable to or superior to those obtained with [⁶⁸

Margret Schottelius, Jakub Šimeček, Frauke Hoffmann, Marina Willibald… in EJNMMI Research (2015)

Article

The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity

The overexpression of the chemokine receptor 4 (CXCR4) in different epithelial, mesenchymal, and hematopoietic cancers makes CXCR4 an attractive diagnostic and therapeutic target. However, targeting the CXCR4 ...

Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger… in EJNMMI Research (2016)

Article

Preclinical evaluation of [⁶⁸Ga]NOTA-pentixafor for PET imaging of CXCR4 expression in vivo — a comparison to [⁶⁸Ga]pentixafor

Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [⁶⁸Ga]pentixafor has emerged a...

Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger… in EJNMMI Research (2016)

Article

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using ¹¹¹In-tilmanocept

Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The ma...

Zohreh Varasteh, Fabien Hyafil, Nadège Anizan, Devy Diallo… in EJNMMI Research (2017)

Article

Response assessment with the CXCR4-directed positron emission tomography tracer [⁶⁸Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger… in EJNMMI Research (2017)

Article

Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis

Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer… in EJNMMI Research (2018)

Article

Synthesis and preclinical evaluation of novel ¹⁸F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with ¹⁸F-DCFPyl and ¹⁸F-PSMA-1007

Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...

Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius… in EJNMMI Research (2018)

Article

Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expre...

Martina Wirtz, Alexander Schmidt, Margret Schottelius, Stephanie Robu… in EJNMMI Research (2018)

Article

PET imaging of chemokine receptor CXCR4 in patients with primary and recurrent breast carcinoma

CXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis wa...

Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske… in EJNMMI Research (2018)

Article

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using ⁶⁸Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD20...

Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster… in EJNMMI Research (2019)

Article

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ l...

Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer… in EJNMMI Research (2019)

Article

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the ...

Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer… in EJNMMI Research (2019)

Article

First In-Human Medical Imaging with a PASylated ⁸⁹Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer

PASylation® offers the ability to systematically tune and optimize the pharmacokinetics of protein tracers for molecular imaging. Here we report the first clinical translation of a PASylated Fab fragment (⁸⁹Zr∙Df...

Antonia Richter, Karina Knorr, Martin Schlapschy… in Nuclear Medicine and Molecular Imaging (2020)