19 Result(s)
within
Markus M. Lerch
Biomedicine
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Article
Open AccessLack of association between proton pump inhibitor use and brain aging: a cross-sectional study
Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age,...
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Article
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microb...
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Article
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpower...
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Reference Work Entry In depth
Approaching Pancreatic Cancer Phenotypes via Metabolomics
Metabolomics, one of the latest omics’ technologies, focuses on the global, quantitative, and simultaneous measurement of endogenous metabolites in a biological sample. Investigation of either individual metab...
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Article
Open AccessThe impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer
Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease.
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Article
Liver injury and genetic polymorphisms in the cytochrome P450 and UDP-glucuronosyltransferase genes
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Living Reference Work Entry In depth
Approaching Pancreatic Cancer Phenotypes via Metabolomics
Metabolomics, one of the latest omics’ technologies, focuses on the global, quantitative, and simultaneous measurement of endogenous metabolites in a biological sample. Investigation of either individual metab...
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Article
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus and identify new association signals in MBOAT7 and TM...
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Article
Genetic polymorphisms in the UDP-glucuronosyltransferase UGT1A7 gene in patients with acute liver failure after kava-kava consumption
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Article
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis
Anders Molven and colleagues show that a recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. The hybrid allele is associated with approximately fivefol...
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Article
Open AccessCohort profile: Greifswald approach to individualized medicine (GANI_MED)
Individualized Medicine aims at providing optimal treatment for an individual patient at a given time based on his specific genetic and molecular characteristics. This requires excellent clinical stratificatio...
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Article
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one...
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Article
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
John Chambers and colleagues report a genome-wide association study for markers of liver function. They identify 42 loci associated with concentrations of one or more liver enzymes in plasma, and use a range o...
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Article
Open AccessIn vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model
Pancreatic cancer is the fourth leading cause of tumour death in the western world. However, appropriate tumour models are scarce. Here we present a syngeneic murine pancreatic cancer model using 7 Tesla MRI a...
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Article
Open AccessMetastatic behaviour of primary human tumours in a zebrafish xenotransplantation model
Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cum...
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Article
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1)1 and the pancreatic secretory trypsin inhibitor (SPINK1)2 are associated with ch...
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Article
Correction: Corrigendum: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
Nat. Genet. 37, 1345–1350 (2005). The name of the 23rd author (Arif B. Ekici) has now been included in the author list. Arif B. Ekici is at the Institute of Human Genetics, University of Erlangen-Nuremberg, Sc...
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Article
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
Johanson-Blizzard syndrome (OMIM 243800) is an autosomal recessive disorder that includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental re...
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Chapter
The Role of Cysteine Proteases in Intracellular Pancreatic Serine Protease Activation
Autodigestion by proteolytic enzymes is thought to represent the critical mechanism by which acute pancreatitis is initiated. Where and why pancreatic proteases, which are physiologically stored and secreted a...
