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Article
Open AccessInitiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-...
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Article
Open AccessNutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits
Malnutrition is a common complication of chronic pancreatitis (CP) and liver cirrhosis (LC). Inadequate food intake is considered a relevant driver of malnutrition in both entities. However, the contribution o...
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Article
Open AccessIRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis
Acute pancreatitis (AP), which is characterized by self-digestion of the pancreas by its own prematurely activated digestive proteases, is a major reason for hospitalization. The autodigestive process causes n...
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Living Reference Work Entry In depth
Intensivtherapie bei akuter Pankreatitis
Die akute Pankreatitis ist die häufigste nicht-maligne Diagnose in der Gastroenterologie, die zu einem stationären Aufenthalt führt. Die Inzidenz liegt in Deutschland zwischen 13 und 43/100.000 Einwohnern. Die...
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Article
Open AccessIdentification of early predictors for infected necrosis in acute pancreatitis
In acute pancreatitis, secondary infection of pancreatic necrosis is a complication that mostly necessitates interventional therapy. A reliable prediction of infected necrotizing pancreatitis would enable an e...
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Article
Open AccessIn mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response
Chronic pancreatitis (CP) is characterized by chronic inflammation and the progressive fibrotic replacement of exocrine and endocrine pancreatic tissue. We identify Treg cells as central regulators of the fibr...
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Article
Gendern in der Medizin – ein Appell
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Article
Open AccessLack of association between proton pump inhibitor use and brain aging: a cross-sectional study
Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age,...
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Article
Open AccessAssociation of hepatic steatosis derived from ultrasound and quantitative MRI with prediabetes in the general population
The aim of our study was to investigate the association of hepatic steatosis derived from quantitative ultrasound and magnetic resonance imaging (MRI) with prediabetes in a large population-based study conduct...
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Article
Open AccessQuality of life and olfactory function after suprasellar craniopharyngioma surgery—a single-center experience comparing transcranial and endoscopic endonasal approaches
The endoscopic endonasal approach to suprasellar craniopharyngiomas has become popular as alternative to transcranial approaches. However, the literature lacks data regarding quality of life and olfactory func...
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Article
Open AccessCarrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implic...
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Article
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microb...
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Article
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpower...
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Article
Open AccessZelluläre Pathomechanismen der akuten Pankreatitis
Das exokrine Pankreas produziert und sezerniert alle für die Verdauung wichtigen Enzyme. Die akute Pankreatitis ist eine Entzündungsreaktion der Bauchspeicheldrüse, die durch die vorzeitige Aktivierung dieser ...
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Article
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or au...
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Chapter
Metabolic Biomarkers of Pancreatic Cancer
Patients with pancreatic cancer (PDAC) are usually diagnosed in advanced often incurable disease stages. Sensitive and specific markers are critical to support diagnostic and therapeutic management. Early non-...
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Article
Open AccessHelicobacter pylori infection associates with fecal microbiota composition and diversity
Helicobacter (H.) pylori is the most important cause for peptic ulcer disease and a risk factor for gastric carcinoma. How colonization with H. pylori affects the intestinal microbiota composition in humans is un...
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Article
Open AccessAbsence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis
Acute pancreatitis is characterized by an early intracellular protease activation and invasion of leukocytes into the pancreas. Cathepsins constitute a large group of lysosomal enzymes, that have been shown to...
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Article
Open AccessAssociations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
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Article
Open AccessPhenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9.
