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  1. No Access

    Chapter

    Pankreaskrankheiten

    Das Pankreas besitzt eine zentrale Rolle in der Aufschließung der Nahrungsbestandteile und der Regulation des Blutzuckerspiegels. Neben der zystischen Fibrose ist die Pankreatitis die häufigste Erkrankung des ...

    Heiko Witt in Pädiatrie (2020)

  2. No Access

    Living Reference Work Entry In depth

    Pankreaskrankheiten bei Kindern und Jugendlichen

    Das Pankreas besitzt eine zentrale Rolle in der Aufschließung der Nahrungsbestandteile und der Regulation des Blutzuckerspiegels. Neben der zystischen Fibrose ist die Pankreatitis die häufigste Erkrankung des ...

    Heiko Witt in Pädiatrie

  3. No Access

    Article

    Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters

    Although increased dietary fructose consumption is associated with metabolic impairments, the mechanisms and regulation of intestinal fructose absorption are poorly understood. GLUT5 is considered to be the ma...

    Karolin Ebert, Maren Ludwig… in The Journal of Membrane Biology (2017)

  4. Article

    Open Access

    Fructose malabsorption

    Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogene...

    Karolin Ebert, Heiko Witt in Molecular and Cellular Pediatrics (2016)

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  5. No Access

    Article

    A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

    Anders Molven and colleagues show that a recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. The hybrid allele is associated with approximately fivefol...

    Karianne Fjeld, Frank Ulrich Weiss, Denise Lasher, Jonas Rosendahl… in Nature Genetics (2015)

  6. No Access

    Article

    Variants in CPA1 are strongly associated with early onset chronic pancreatitis

    Heiko Witt, Miklós Sahin-Tóth and colleagues show that loss-of-function variants in CPA1 are strongly associated with early onset chronic pancreatitis. On the basis of their findings, they propose that the mechan...

    Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen… in Nature Genetics (2013)

  7. No Access

    Article

    New modifier loci in cystic fibrosis

    A genome-wide association study has identified two new loci modifying pulmonary disease severity in cystic fibrosis. Although this data offers clues to pathways influencing pulmonary function, the underlying g...

    Heiko Witt in Nature Genetics (2011)

  8. Article

    Interleukin 18 Promoter Variants (−137G>C and −607C>A) in Patients with Chronic Hepatitis C: Association with Treatment Response

    Recently, two functional IL18 promoter variants, −607C>A (rs1946518) and −137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for tre...

    Stephan L. Haas, Christel Weiß, Peter Bugert, Jutta Gundt… in Journal of Clinical Immunology (2009)

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  9. No Access

    Article

    Genetic aspects of tropical calcific pancreatitis

    Tropical calcific pancreatitis (TCP) is a subtype of chronic pancreatitis which is unique to tropical regions. Patients present at young age with recurrent abdominal pain, nutritional deficiencies, and insulin...

    Heiko Witt, Eesh Bhatia in Reviews in Endocrine and Metabolic Disorders (2008)

  10. No Access

    Article

    Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

    Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the gene encoding the trypsin-degra...

    Jonas Rosendahl, Heiko Witt, Richárd Szmola, Eesh Bhatia, Béla Ózsvári… in Nature Genetics (2008)

  11. No Access

    Article

    Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer

    Keratin 8 (KRT8) is one of the major intermediate filament proteins expressed in single-layered epithelia of the gastrointestinal tract. Transgenic mice over-expressing human KRT8 display pancreatic mononuclear i...

    Matthias Treiber, Hans-Ulrich Schulz, Olfert Landt… in Journal of Molecular Medicine (2006)

  12. No Access

    Article

    A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

    Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1)1 and the pancreatic secretory trypsin inhibitor (SPINK1)2 are associated with ch...

    Heiko Witt, Miklós Sahin-Tóth, Olfert Landt, Jian-Min Chen, Thilo Kähne… in Nature Genetics (2006)

  13. Article

    Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy

    Andreas Perrot, Hajo Schmidt-Traub, Bernard Hoffmann… in Journal of Molecular Medicine (2005)

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  14. No Access

    Article

    Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

    Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all cases, no aetiological factor can be found, and these patients are classified as h...

    Heiko Witt, Werner Luck, Hans Christian Hennies, Martin Claßen… in Nature Genetics (2000)

  15. Article

    HFE gene mutation and transferrin saturation in very low birthweight infants

    Rolf F Maier, Heiko Witt, Eberhard Mönch, Christoph Bührer in Pediatric Research (1999)

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