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  1. Article

    Open Access

    WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

    WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mo...

    Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau… in Nature Communications (2023)

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  2. Article

    Open Access

    FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

    Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activat...

    Marion Espéli, Rachael Bashford-Rogers, John M. Sowerby… in Nature Communications (2019)

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