-
Article
Open AccessBioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts
Visual impairment from corneal stromal disease affects millions worldwide. We describe a cell-free engineered corneal tissue, bioengineered porcine construct, double crosslinked (BPCDX) and a minimally invasiv...
-
Article
Open AccessA porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery
Biomaterials designed to replace the diseased cornea could be used to treat corneal blindness where human donor tissue is in short supply, but challenges are the integration of biomaterials with host tissue an...
-
Article
Open AccessTime-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization
Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex ...
-
Article
Open AccessGenome-wide expression datasets of anti-VEGF and dexamethasone treatment of angiogenesis in the rat cornea
Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents are in wide...
-
Article
Open AccessGenome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea
Angiogenesis as a pathological process in the eye can lead to blindness. In the cornea, suppression of angiogenesis by anti-VEGF treatment is only partially effective while steroids, although effective in trea...
-
Article
Open AccessA microarray whole-genome gene expression dataset in a rat model of inflammatory corneal angiogenesis
In angiogenesis with concurrent inflammation, many pathways are activated, some linked to VEGF and others largely VEGF-independent. Pathways involving inflammatory mediators, chemokines, and micro-RNAs may pla...
-
Article
Open AccessFactors regulating capillary remodeling in a reversible model of inflammatory corneal angiogenesis
Newly formed microcapillary networks arising in adult organisms by angiogenic and inflammatory stimuli contribute to pathologies such as corneal and retinal blindness, tumor growth and metastasis. Therapeutic ...
