13 Result(s)

Article

A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain

Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in th...

Takayuki Sakai, Aya Ogata, Hiroshi Ikenuma… in EJNMMI Radiopharmacy and Chemistry (2024)

Article

Publisher Correction: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia

Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S. Andhey… in Nature Immunology (2023)

Article

Epilepsy surgery without lipoma removal for temporal lobe epilepsy associated with lipoma in the Sylvian fissure

Epileptic seizure is the common symptom associated with lipomas in the Sylvian fissure (Sylvian lipomas). Removal of these lipomas carries risks of hemorrhage and brain damage. We report a surgical strategy of...

Kazuki Nomura, Hiroharu Suzuki, Yasushi Iimura, Takumi Mitsuhashi… in Acta Neurochirurgica (2023)

Article

Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex

In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may be triggered by an increase in the TDP-4...

Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito… in Communications Biology (2021)

Article

Correction to: A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features

An amendment to this paper has been published and can be accessed via the original article.

Makoto Sainouchi, Yuya Hatano, Mari Tada… in Acta Neuropathologica Communications (2021)

Article

A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features

Makoto Sainouchi, Yuya Hatano, Mari Tada… in Acta Neuropathologica Communications (2021)

Article

Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings

Rie Saito, Norikazu Hara, Mari Tada, Yoshiaki Honma… in Acta Neuropathologica Communications (2020)

Article

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studi...

Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki… in Acta Neuropathologica Communications (2019)

Article

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are types of major TDP-43 (43-kDa TAR DNA-binding protein) proteinopathy. Cortical TDP-43 pathology has been analyzed in detail ...

Ryoko Takeuchi, Mari Tada, Atsushi Shiga… in Acta Neuropathologica Communications (2016)

Article

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy

p25α/tubulin polymerization promoting protein (TPPP) is an oligodendroglial protein that plays crucial roles including myelination, and the stabilization of microtubules. In multiple system atrophy (MSA), TPPP...

Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki… in Acta Neuropathologica Communications (2014)