36 Result(s)

Article

Coagulation in sepsis: all bugs bite equally

Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experi...

Marcel Levi, Tom van der Poll in Critical Care (2004)

Article

Factors that predict outcome of intensive care treatment in very elderly patients: a review

Advanced age is thought to be associated with increased mortality in critically ill patients. This report reviews available data on factors that determine outcome, on the value of prognostic models, and on pre...

Sophia E de Rooij, Ameen Abu-Hanna, Marcel Levi, Evert de Jonge in Critical Care (2005)

Article

Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study

Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieve...

Anne-Cornélie JM de Pont, Kamran Bakhtiari, Barbara A Hutten… in Critical Care (2005)

Article

Antithrombin in sepsis revisited

As the pivotal phase III randomized controlled clinical trial on antithrombin concentrate in patients with severe sepsis did not show a beneficial effect of antithrombin treatment on 28-day mortality, the inte...

Marcel Levi in Critical Care (2005)

Article

Coagulation abnormalities in critically ill patients

Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. Ther...

Marcel Levi, Steven M Opal in Critical Care (2006)

Article

The effects of continuous venovenous hemofiltration on coagulation activation

The mechanism of coagulation activation during continuous venovenous hemofiltration (CVVH) has not yet been elucidated. Insight into the mechanism(s) of hemostatic activation within the extracorporeal circuit ...

Catherine SC Bouman, Anne-Cornélie JM de Pont, Joost CM Meijers… in Critical Care (2006)

Article

Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage

Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication seen in patients with autoimmune disorders and patients treated with chemotherapy or after hematopoietic stem cell transplantation. The cli...

Lars Heslet, Jorn Dalsgaard Nielsen, Marcel Levi, Henrik Sengeløv… in Critical Care (2006)

Article

Identification of high-risk subgroups in very elderly intensive care unit patients

Current prognostic models for intensive care unit (ICU) patients have not been specifically developed or validated in the very elderly. The aim of this study was to develop a prognostic model for ICU patients ...

Sophia E de Rooij, Ameen Abu-Hanna, Marcel Levi, Evert de Jonge in Critical Care (2007)

Article

Influenza infection and risk of acute pulmonary embolism

Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.

Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor EA Gerdes… in Thrombosis Journal (2007)

Article

Recombinant human activated protein C: current insights into its mechanism of action

Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and ...

Marcel Levi, Tom van der Poll in Critical Care (2007)

Article

The inflammation–coagulation axis as an important intermediate pathway in acute lung injury

Markers of inflammation, coagulation, and fibrinolysis predict an adverse outcome in patients with sepsis. These markers also seem predictive of an adverse outcome in patients with localized infection and infl...

Marcel Levi, Marcus Schultz in Critical Care (2008)

Article

Improvement in the regulation of the vitamin K antagonist acenocoumarol after a standard initial dose regimen: prospective validation of a prescription model

Background In a retrospective study we have developed a model which determines the dose of acenocoumarol based on the age of the patient and on the first INR obtained after a standard ini...

Johanna H. H. Van Geest-Daalderop… in Journal of Thrombosis and Thrombolysis (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

The safety of using heparin concomitantly with drotrecogin alfa (activated) {DrotAA} was explored in the XPRESS study. No heparin effect on mortality was observed. Safety results from that study are explored i...

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats

Disturbed alveolar fibrin turnover is a cardinal feature of severe pneumonia. Clinical studies suggest that natural inhibitors of coagulation exert lung-protective effects via anticoagulant and possibly also a...

Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar… in Critical Care (2009)

Article

Adequate thromboprophylaxis in critically ill patients

Venous thromboembolism is a relatively frequently occurring complication in critically ill patients admitted to the ICU despite prophylactic treatment with subcutaneous low molecular weight heparin. Several st...

Marcel Levi in Critical Care (2010)

Article

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angio...

Tom Bowen, Marco Cicardi, Henriette Farkas… in Allergy, Asthma & Clinical Immunology (2010)

Article

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2010)

Article

Treatment with recombinant human activated protein C: one size does not fit all

Protein C plays an important role in the coagulopathy associated with sepsis and probably also in the pathogenesis of sepsis-induced organ dysfunction. Plasma levels of protein C strongly correlate with clinic...

Marcel Levi in Critical Care (2011)

Article

Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study

Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...

Pieter R Tuinman, Alexander P Vlaar, Alexander D Cornet, Jorrit J Hofstra… in Critical Care (2011)