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Article
Open AccessEffect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial
Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. H...
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Article
Open AccessOverexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia
During pneumonia, inflammation and coagulation are activated as part of anti-bacterial host defense. Activated protein C (APC) has anticoagulant and anti-inflammatory properties and until recently was a regist...
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Article
Open AccessActivation of coagulation and tissue fibrin deposition in experimental influenza in ferrets
Epidemiological studies relate influenza infection with vascular diseases like myocardial infarction. The hypothesis that influenza infection has procoagulant effects on humans has been investigated by experim...
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Article
Open AccessUtility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review
Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoa...
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Article
Open AccessEvaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study
Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection...
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Article
Open AccessHigh-density lipoprotein proteome dynamics in human endotoxemia
A large variety of proteins involved in inflammation, coagulation, lipid-oxidation and lipid metabolism have been associated with high-density lipoprotein (HDL) and it is anticipated that changes in the HDL pr...
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Article
Open AccessBlood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...
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Article
Open AccessMarkers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir
Abacavir (ABC) treatment has been associated with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infe...
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Article
Open AccessPharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study
In patients with suspected heparin-induced thrombocytopenia (HIT) who need renal replacement therapy, a nonheparin anticoagulant has to be chosen to prevent thrombosis in the extracorporeal circuit. Danaparoid...
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Article
Open AccessSELDI-TOF mass spectrometry of High-Density Lipoprotein
High-Density Lipoprotein (HDL), one of the main plasma lipoproteins, serves as a docking station for proteins involved in inflammation, coagulation, and lipid metabolism.
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Article
Open AccessThe effects of continuous venovenous hemofiltration on coagulation activation
The mechanism of coagulation activation during continuous venovenous hemofiltration (CVVH) has not yet been elucidated. Insight into the mechanism(s) of hemostatic activation within the extracorporeal circuit ...
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Article
Open AccessAnalysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes
The use of mouse models for the study of thrombotic disorders has gained increasing importance. Methods for measurement of coagulation activation in mice are, however, scarce. The primary aim of this study was...
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Article
Open AccessRecombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study
Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieve...
