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Article
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
360 million people are chronically infected with the human hepatitis B virus (HBV) and are consequently prone to develop liver cirrhosis and hepatocellular carcinoma1. As approved therapeutic regimens—which modul...
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Article
RGB marking facilitates multicolor clonal cell tracking
Kristoffer Weber et al. describe a new lentiviral vector-mediated RGB (red, green and blue) multicolor cell marking technique for analyzing clonal cell fates in vitro and in vivo. Here they use RGB marking to ass...
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Article
Experimental models and therapeutic approaches for HBV
Liver disease associated to persistent infection with the hepatitis B virus (HBV) continues to be a major health problem of global impact. In spite of the existence of an effective vaccine, approximately 360 m...
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Article
Open AccessNew foe treated with old guns – supportive role of steroids in the treatment of acute severe hepatitis E
Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. Howev...
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Article
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Inhibiting virus cell entry by targeting tight junctions cures HCV infection in mice.
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Chapter
Experimental Models: Cell Culture and Animal Models
Experimental models are indispensable tools for studying the biology of virus infection and for drug development. The narrow host range of hepatitis B virus (HBV), the lack of robust in vitro infection systems...
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Article
Open AccessAttenuated viral hepatitis in Trem1−/− mice is associated with reduced inflammatory activity of neutrophils
TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in live...
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Protocol
Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
The hepatitis B virus (HBV) is the causative agent for chronic hepatitis B infection, which affects an estimate of 240 million people worldwide and puts them at risk of develo** terminal liver disease. The l...
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Article
Open AccessBoth interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice
Co-infection with hepatitis B (HBV) and D virus (HDV) is associated with the most severe course of liver disease. Interferon represents the only treatment currently approved. However, knowledge about the impac...
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Article
Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center
To determine epidemiological, clinical and laboratory characteristics of leptospirosis, 24 consecutive patients diagnosed with the infection between 2011 and 2017 at the University Medical Center Hamburg-Eppen...
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Article
Open AccessDAMIAN: an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples
We describe DAMIAN, an open source bioinformatics tool designed for the identification of pathogenic microorganisms in diagnostic samples. By using authentic clinical samples and comparing our results to those...
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Article
Open AccessHigh rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: longitudinal analysis of a German cohort
Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognost...
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Article
Open AccessImplementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis
Infectious meningitis is a serious disease and patient outcome relies on fast and reliable diagnostics. A syndromic panel testing approach like the FilmArray ME can accelerate diagnosis and therefore decrease ...
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Article
Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany
Autopsies of deceased with a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can provide important insights into the novel disease and its course. Furthermore, autopsies are es...
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Article
Correction to: Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany
The affiliation of the author Martin Aepfelbacher was incorrectly assigned in the manuscript. Martin Aepfelbacher is affiliated to the Institute of Microbiology, University Medical Center Hamburg-Eppendorf, Ha...
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Article
Open AccessGermany’s first COVID-19 deceased: a 59-year-old man presenting with diffuse alveolar damage due to SARS-CoV-2 infection
Clinical characterization of COVID-19 (Corona Virus Disease 2019) is being performed worldwide to gain insights into the pathogenesis and course of the disease. Little is known regarding morphological findings...
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Article
Open AccessAntibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis
Despite improvements in diagnosis, intensive-care medicine and surgical technique, the mortality of patients with secondary peritonitis is still high. Early and aggressive empiric antibiotic treatment has stro...
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Article
Open AccessControl of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients
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Article
Open AccessComparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with...
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Article
Open AccessSevere liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunctio...
