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Open AccessRe-analysis of whole-exome sequencing data uncovers novel diagnostic variants and improves molecular diagnostic yields for sudden death and idiopathic diseases
Whole-exome sequencing (WES) has become an efficient diagnostic test for patients with likely monogenic conditions such as rare idiopathic diseases or sudden unexplained death. Yet, many cases remain undiagnos...
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Open AccessSG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort
Whole genome and exome sequencing usually include reads containing mitochondrial DNA (mtDNA). Yet, state-of-the-art pipelines and services for human nuclear genome variant calling and annotation do not handle ...
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Article
Open AccessConformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158
DNA replication initiation is a vital and tightly regulated step in all replicons and requires an initiator factor that specifically recognizes the DNA replication origin and starts replication. RepB from the ...
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Article
Open AccessBioSuper: A web tool for the superimposition of biomolecules and assemblies with rotational symmetry
Most of the proteins in the Protein Data Bank (PDB) are oligomeric complexes consisting of two or more subunits that associate by rotational or helical symmetries. Despite the myriad of superimposition tools i...
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Protocol
Ligand-Guided Receptor Optimization
Receptor models generated by homology or even obtained by crystallography often have their binding pockets suboptimal for ligand docking and virtual screening applications due to insufficient accuracy or induc...
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Article
Open AccessComparison of molecular dynamics and superfamily spaces of protein domain deformation
It is well known the strong relationship between protein structure and flexibility, on one hand, and biological protein function, on the other hand. Technically, protein flexibility exploration is an essential...
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Chapter
Data Mining of Molecular Dynamic Trajectories of Nucleic Acids
