-
Article
Open AccessMonkeypox virus genomic accordion strategies
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or s...
-
Article
Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones
Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleos...
-
Article
Open AccessLiver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease
Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT protei...
-
Article
Open AccessBacteroides fragilis metabolises exopolysaccharides produced by bifidobacteria
Bacteroides fragilis is the most frequent species at the human intestinal mucosal surface, it contributes to the maturation of the immune system although is also considered as an oppor...
-
Article
Open AccessPioneer transcription factor FoxA is positioned on hypersensitive nucleosomes at active enhancers
-
Article
Open AccessAnalysis of strain relatedness using High Resolution Melting in a case of recurrent candiduria
Several genoty** protocols have been described to study Candida albicans strains with different sensitivity values. In this study we have analyzed the genetic relatedness and the antifungal susceptibility of se...
-
Article
Open AccessComparison of molecular dynamics and superfamily spaces of protein domain deformation
It is well known the strong relationship between protein structure and flexibility, on one hand, and biological protein function, on the other hand. Technically, protein flexibility exploration is an essential...
