21 Result(s)

Article

PI3K inhibition by BKM120 results in anti-proliferative effects on corticotroph tumor cells

Cushing's disease is associated with significant morbidity; thus, additional tumor-directed drugs with the potential to exert antineoplastic effects on corticotroph adenoma cells are desired. The phosphoinosit...

H. A. Oliveira, A. C. Bueno, R. S. Pugliesi… in Journal of Endocrinological Investigation (2022)

Article

Absence of TERT promoter mutations in pituitary adenomas

C. S. Martins, M. de Castro, R. T. Calado in Journal of Endocrinological Investigation (2016)

Chapter and Conference Paper

Black Carbon Exposure of Schoolchildren in Barcelona

Black carbon (BC; a good tracer of road traffic emissions) concentrations from personal monitoring of 46 school children showed the highest levels in comparison with the corresponding fixed stations in schools...

I. Rivas, L. Bouso, D. Donaire, M. Pandolfi… in Air Pollution Modeling and its Application… (2016)

Article

Telomere length and telomerase expression in pituitary tumors

Telomere dysfunction and telomerase activation underlie cancer transformation. This study aims to investigate the contribution of telomere biology to pituitary tumor behavior.

C. S. Martins, B. A. Santana-Lemos… in Journal of Endocrinological Investigation (2015)

Article

Regional climate modelling in CLARIS-LPB: a concerted approach towards twentyfirst century projections of regional temperature and precipitation over South America

The results of an ensemble of regional climate model (RCM) simulations over South America are presented. This is the first coordinated exercise of regional climate modelling studies over the continent, as par...

E. Sánchez, S. Solman, A. R. C. Remedio, H. Berbery, P. Samuelsson… in Climate Dynamics (2015)

Article

Evaluation of an ensemble of regional climate model simulations over South America driven by the ERA-Interim reanalysis: model performance and uncertainties

The capability of a set of 7 coordinated regional climate model simulations performed in the framework of the CLARIS-LPB Project in reproducing the mean climate conditions over the South American continent has...

Silvina A. Solman, E. Sanchez, P. Samuelsson, R. P. da Rocha, L. Li… in Climate Dynamics (2013)

Article

Performance of a multi-RCM ensemble for South Eastern South America

The ability of four regional climate models to reproduce the present-day South American climate is examined with emphasis on La Plata Basin. Models were integrated for the period 1991–2000 with initial and lat...

A. F. Carril, C. G. Menéndez, A. R. C. Remedio, F. Robledo… in Climate Dynamics (2012)

Article

Ghrelin and PYY₃₋₃₆ in gastrectomized and vagotomized patients: relations with appetite, energy intake and resting energy expenditure

Reduced food intake, appetite loss and alteration of ghrelin and PYY₃₋₃₆ secretion have been suggested to have a function in the loss of body weight commonly observed after gastrectomy. The objective of this stud...

M M Kamiji, L E A Troncon, J Antunes-Rodrigues… in European Journal of Clinical Nutrition (2010)

Article

Mineralocorticoid receptor p.I180V polymorphism: Association with body mass index and LDL-cholesterol levels

Background/Aims: Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The ai...

F. L. Fernandes-Rosa, A. C. Bueno… in Journal of Endocrinological Investigation (2010)

Article

An intercomparison of regional climate simulations for Europe: assessing uncertainties in model projections

Ten regional climate models (RCM) have been integrated with the standard forcings of the PRUDENCE experiment: IPCC-SRES A2 radiative forcing and Hadley Centre boundary conditions. The response over Europe, cal...

M. Déqué, D. P. Rowell, D. Lüthi, F. Giorgi, J. H. Christensen… in Climatic Change (2007)

Article

The use of a climate-type classification for assessing climate change effects in Europe from an ensemble of nine regional climate models

Making use of the Köppen–Trewartha (K–T) climate classification, we have found that a set of nine high-resolution regional climate models (RCM) are fairly capable of reproducing the current climate in Europe. ...

M. de Castro, C. Gallardo, K. Jylha, H. Tuomenvirta in Climatic Change (2007)

Article

Global high resolution versus Limited Area Model climate change projections over Europe: quantifying confidence level from PRUDENCE results

Four high resolution atmospheric general circulation models (GCMs) have been integrated with the standard forcings of the PRUDENCE experiment: IPCC-SRES A2 radiative forcing and Hadley Centre sea surface tempe...

M. Déqué, R. G. Jones, M. Wild, F. Giorgi, J. H. Christensen… in Climate Dynamics (2005)

Article

The interaction of plasma renin activity and plasma atrial natriuretic peptide in 21-hydroxylase deficiency patients

Plasma renin activity (PRA) determination is the main index used to evaluate the mineralocorticoid control in 21-hydroxylase deficiency (21-OHD). PRA values within or at the upper limit of the age-appropriate ...

C. M. R. Germano, M. de Castro… in Journal of Endocrinological Investigation (2005)

Article

Intracranial Castleman’s disease presenting as hypopituitarism

Castleman’s disease is an atypical lymphoproliferative disorder that may present as a localized or multicentric form. The involvement of the central nervous system is rare. We describe here a case of Castleman...

L. T. Ribeiro, G. N. Simão, A. L. M. Matos, C. G. Carlotti Jr… in Neuroradiology (2004)

Article

The higher expression of α and β isoforms of the human glucocorticoid receptor in leukemic B-progenitors compared to normal CD10⁺ BM cells does not correlate with methylprednisolone-induced apoptosis

L M M Albuquerque, A B Garcia, J O Mengel, R P Falcão, M de Castro, E M Rego in Leukemia (2004)

Chapter and Conference Paper

Regional IPCC Projections untill 2100 in the Mediterranean Area

Over the last forty years much evidence has been accumulated as to how human activities can ultimately affect the global climate of our planet. However the extreme complexity of the Earth's climate system make...

M. de Castro, C. Gallardo, S. Calabria in Environmental Challenges in the Mediterran… (2004)

Chapter

Natural Alignment and Cooling in Seeded Supersonic Free Jets: Experiments and a Quantum Mechanical View

A simple and natural source of cold and aligned molecules involves the use of molecular beams seeded with lighter carrier gases: collisions occurring during the supersonic expansion can produce molecules in th...

V. Aquilanti, D. Ascenzi, D. Cappelletti, M. de Castro… in Atomic and Molecular Beams (2001)

Article

Genotype and phenotype analysis of Friedreich's ataxia compound heterozygous patients

Friedreich's ataxia is caused by mutations in the FRDA gene that encodes frataxin, a nuclear-encoded mitochondrial protein. Most patients are homozygous for the expansion of a GAA triplet repeat within the FRDA ...

M. De Castro, J. García-Planells, E. Monrós, J. Cañizares… in Human Genetics (2000)

Article

Intronic GAA triplet repeat expansion in Friedreich’s ataxia presenting with pure sensory ataxia

J. Berciano, O. Combarros, M. De Castro, F. Palau in Journal of Neurology (1997)