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  1. Article

    Open Access

    STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

    Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the β-cell mass mainly through proliferation of pre-existing and newly formed β-cells. The molecular mechanism governing this process...

    S De Groef, D Renmans, Y Cai, G Leuckx, S Roels, W Staels… in Cell Death & Disease (2016)

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  2. Article

    Open Access

    Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

    We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)+ progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3

    M Van de Casteele, G Leuckx, L Baeyens, Y Cai, Y Yuchi, V Coppens… in Cell Death & Disease (2013)

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  3. Article

    Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells

    Efficient stimulation of cycling activity in cultured beta cells would allow the design of new strategies for cell therapy in diabetes. Neural crest stem cells (NCSCs) play a role in beta cell development and ...

    G. Grouwels, S. Vasylovska, J. Olerud, G. Leuckx, A. Ngamjariyawat… in Diabetologia (2012)

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  4. Article

    Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells

    In the human pancreas, a close topographic relationship exists between duct cells and beta cells. This explains the high proportion of duct cells in isolated human islet preparations. We investigated whether h...

    B. Movahedi, M. Van de Casteele, N. Caluwé, G. Stangé, K. Breckpot… in Diabetologia (2004)

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  5. Article

    AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

    Prolonged exposure of beta cells to low glucose concentrations triggers their apoptosis and is known to activate AMP-activated protein kinase (AMPK) in beta cell lines. We examined whether prolonged activation...

    B. A. Kefas, H. Heimberg, S. Vaulont, D. Meisse, L. Hue, D. Pipeleers… in Diabetologia (2003)

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  6. No Access

    Article

    Hypercalcemia, monoclonal protein, and osteolytic bone lesions in chronic lymphocytic leukemia

    We describe a patient with a long history of typical chronic lymphocytic leukemia (CLL) who developed hypercalcemia, osteolytic bone lesions, and a monoclonal protein, all features of a secretory plasma cell d...

    M. Van de Casteele, G. E. G. Verhoef, H. Demuynck, P. Zacheé… in Annals of Hematology (1994)