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Article
Induction of an immune network cascade in cancer patients treated with monoclonal antibodies (ab1)
The antitumor effector functions of unconjugated monoclonal antibodies (mAb) in cancer therapy are not fully understood. Direct cytotoxic mechanisms such as antibody-dependent cellular cytotoxicity, complement...
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Chapter
Human Monoclonal Antibodies Produced by Epstein-Barr Virus Immortalized Cell Lines: Technical and Theoretical Principles
Continuous cell lines that produce monoclonal antibodies are now routinely established from mouse and rat origin according to the hybridoma method (Köhler and Milstein, 1975). This method is still, to a large ...
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Chapter and Conference Paper
Establishment of Specific Antibody Producing Human Lines by Antigen Preselection and EBV-Transformation
Human lymphocytes can be immortalized (“transformed”) by laboratory (B95-8) isolates of Epstein Barr virus (EBV) (1). Following primary infection, the virus induces EBNA, the EBV-determined nuclear antigen, in...