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Article
Open AccessSomatic rearrangement of the TP63 gene preceding development of mycosis fungoides with aggressive clinical course
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Article
Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas
Ahi-1 (Abelson helper integration site 1) is a novel gene frequently activated by provirus insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by ...
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Article
Cultured human keratinocytes as a peripheral source of mRNA for tyrosine hydroxylase and aromaticl-amino acid decarboxylase
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Article
Increased monoamine oxidase A activity in the epidermis of patients with vitiligo
Human keratinocytes under in vitro conditions synthesize norepinephrine and epinephrine, whereas melanocytes lack this capacity. Keratinocytes established from lesional and nonlesional skin of patients with vi...
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Article
Increased in vitro expression of beta2-adrenoceptors in differentiating lesional keratinocytes of vitiligo patients
Keratinocytes were established in serum-free culture medium from lesional and nonlesional skin of a patient with vitiligo (skin type III) and from an age-matched healthy control subject. Both differentiating a...
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Article
Interleukin-6 in psoriasis: expression and mitogenicity studies
InterIeukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further exa...
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Article
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients
A comparative study of the antioxidant enzymes superoxide dismutase, catalase, glutathione reductase and thioredoxin reductase was undertaken in two families with xeroderma pigmentosum (XP) and in healthy cont...
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Article
Regulation of thioredoxin reductase by calcium in Hermansky-Pudlak syndrome
Cell cultures of keratinocytes, established from four Hermansky-Pudlak, syndrome (HPS) homozygotes yielded low membrane-associated thioredoxin reductase activities compared with normal healthy adult controls. ...
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Chapter and Conference Paper
New Therapies
We have recently identified and treated three patients with severe α-1-antitrypsin deficiency who developed progressive, destructive panniculitis. In addition, 3 patients with heterozygous, α-1-antitrypsin def...