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  1. No Access

    Article

    Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

    Busulfan, the corner stone of hematopoietic stem cell transplantation regimens, has a narrow therapeutic window. Therapeutic drug monitoring (TDM)-guided dosing to reach the conventional area under the concent...

    M Philippe, S Goutelle, J Guitton, X Fonrose, C Bergeron… in Bone Marrow Transplantation (2016)

  2. No Access

    Chapter

    Spezifische Belastungsmuster des Alpinsports

    Grundlage fast aller alpinen Sportarten ist das relativ starke Gefälle, das man im alpinen Bereich vorfindet. Neben dem Bergsteigen gibt es eine Vielzahl von Sportarten, die im alpinen Bereich betrieben werden...

    M. Philippe in Alpin- und Höhenmedizin (2015)

  3. No Access

    Article

    Flow intermittence controls leaf litter breakdown in a French temporary alluvial river: the “drying memory”

    The inputs and breakdown of terrestrial leaf litter in streams is a fundamental ecological process that sustains in-stream foodwebs and secondary production. In temporary rivers, litter breakdown is reduced du...

    Thibault Datry, R. Corti, C. Claret, M. Philippe in Aquatic Sciences (2011)

  4. No Access

    Article

    La PCR-temps réel dans le diagnostic des alpha-thalassémies: une alternative d’avenir ?

    Les lésions génétiques associées aux alpha thalassémies sont souvent dues à des délétions touchant un/deux loci de la globine. Le but de cette étude est d’évaluer l’intérêt des températures et courbes de fusio...

    H. Mekouar, C. Debecker, F. Mullier, I. Derclaye, J. -L. Vaerman… in Bio tribune magazine (2009)

  5. No Access

    Article

    Results of a series of 113 ACADEMIA total knee prostheses with a follow-up at 5 years

    One hundred and thirteen patients underwent the implantation of an ACADEMIA prosthesis between 1999 and 2000. The minimum follow-up period was 5 years. The ACADEMIA prosthesis is available in either uncemented...

    M. Philippe, R. Petit in European Journal of Orthopaedic Surgery & Traumatology (2008)

  6. No Access

    Article

    Conservation of the MC domains in eukaryotic release factor eRF3

    Eukaryotic translation termination employs two protein factors, eRF1 and eRF3. Proteins of the eRF3 family each consist of three domains. The N and M domains vary in different species, while the C domains are ...

    G. A. Zhouravleva, O. M. Zemlyanko, C. Le Goff… in Russian Journal of Genetics (2007)

  7. No Access

    Article

    Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3

    We have earlier characterized Saccharomyces cerevisiae strains with mutations of essential SUP45 and SUP35, which code for translation termination factors eRF1 and eRF3, respectively. In this work, the sup45 and

    G. A. Zhouravleva, S. E. Moskalenko, S. V. Chabelskaya, M. Philippe… in Molecular Biology (2006)

  8. No Access

    Article

    Nonsense mutations in the essential gene SUP35 of Saccharomyces cerevisiae are non-lethal

    In the present work we have characterized for the first time non-lethal nonsense mutations in the essential gene SUP35, which codes for the translation termination factor eRF3 in Saccharomyces cerevisiae. The scr...

    S. Chabelskaya, D. Kiktev, S. Inge-Vechtomov… in Molecular Genetics and Genomics (2004)

  9. No Access

    Article

    Characterization of Missense Mutations in the SUP45 Gene of Saccharomyces cerevisiaeEncoding Translation Termination Factor eRF1*

    Collection of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1 has been obtained by different approaches. It has been shown that most of isolated mutat...

    S. E. Moskalenko, G. A. Zhouravleva, M. Y. Soom… in Russian Journal of Genetics (2004)

  10. No Access

    Article

    Identification of a newHLA-DPB1 * 6501 allele in a caucasian individual

    L. F. Versluis, A. Van der Zwan, M. G. J. Tilanus, M. Philippe… in Immunogenetics (1996)

  11. No Access

    Article

    Beta-thalassaemia in indigenous Belgian families: identification of a novel mutation

    The molecular basis of β-thalassemia was investigated at the DNA level in 28 Belgians from 14 unrelated families. All the patients were heterozygous for β-thalassaemia. Seven different mutations were identifi...

    Michel Heusterspreute, Isabelle Derclaye, Jean-Luc Gala, Chris Van Geet… in Human Genetics (1996)

  12. No Access

    Article

    High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis

    Bcl-2 expression and its prognostic value were evaluated using the APAAP technique in 40 ALL patients. Because of a possible synergy between c-myc and bcl-2 proteins in cell lines, we compared 40 ALL of either...

    J. L. Gala, C. Vermylen, G. Cornu, A. Ferrant, J. L. Michaux… in Annals of Hematology (1994)

  13. No Access

    Chapter and Conference Paper

    Clinical Experience with the Bioabsorbable Anastomosis Ring in Bowel Surgery

    In Quenu’s Traité de Technique Chirurgicale of 1955, seven pages deal with anastomotic techniques using different types of buttons. Besides the well-known Murphy button (Murphy 1892), other similar devices are il...

    J. A. Gruwez, J. Lerut, L. Verougstraete… in Intestinal Anastomoses with Bioabsorbable … (1993)

  14. No Access

    Chapter and Conference Paper

    Poly(ADP—Ribose)Polymerase in Xenopus laevis

    Among the different biological systems in which poly(ADP-ribosyl)ation has been studied, cell lines have been widely used, especialy to investigate the role of poly(ADP-ribose)polymerase (PARP) in DNA repair(1). ...

    B. Saulier, F. Simonin, G. Gradwohl, G. de Murcia… in ADP-Ribosylation Reactions (1992)

  15. No Access

    Article

    Evidence for an unusual multifunctional protoreceptor in hormone action

    Contrary to the techniques of mere association, column chromatography has revealed a ‘protoreceptor’ that accepts aldosterone agonists and antagonists only in the physiological target, the kidney, and is absen...

    M. K. Agarwal, J. Paillard, M. Philippe in Experientia (1980)

  16. No Access

    Article

    Evidence for synergism in steroid hormone-receptor association

    A number of glucocorticoids stimulated oestradiol binding to liver cytosol receptor; oestradiol activated glucocorticoid receptor association at a time when it reversed triamcinolone mediated increase in liver...

    M. K. Agarwal, M. Philippe in Experientia (1979)

  17. No Access

    Article

    In situ detection and characterization of DNA polymerase activities in the nucleus of eukaryotic cells

    We have developed a cytoenzymological method for localizing DNA polymerase activities in situ and for studying their responses to various chemical agents or environmental conditions. The incubation mixtures an...

    Ph. Chevaillier, M. Philippe in Chromosoma (1977)

  18. No Access

    Article

    In situ detection of a DNA-polymerase activity in the nuclei of mouse spermatozoa

    A nuclear DNA-polymerase activity has been detected in situ in mouse spermatozoa with a cytochemical method. The acid-insoluble radioactive product obtained after incubation in a mixture containing all four deoxy...

    Ph. Chevaillier, M. Philippe in Chromosoma (1976)