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Chapter and Conference Paper
Adapting P-k-C* Model in Mediterranean Climate for Organic Removal Performance in Horizontal Treatment Wetlands
The P-k-C* is considered as the most suitable in modeling treatment wetland (TW) performance providing a good compromise between accuracy and computational simplicity to assess the degradation processes for se...
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Article
Open AccessThe vortex-driven dynamics of droplets within droplets
Understanding the fluid-structure interaction is crucial for an optimal design and manufacturing of soft mesoscale materials. Multi-core emulsions are a class of soft fluids assembled from cluster configuratio...
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Article
Open AccessHigh CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a predictive biomarker of disease progression in many malignancies, including imatinib-treated chronic myeloid leukemia (CML). Although high CIP2A level...
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Article
Open AccessCombination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer
To assess whether the combination of letrozole, metronomic cyclophosphamide and sorafenib (LCS) is well tolerated and shows activity in primary breast cancer (BC).
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Article
Open AccessProspective neoadjuvant analysis of PET imaging and mechanisms of resistance to Trastuzumab shows role of HIF1 and autophagy
Although Trastuzumab has improved survival of HER2+ breast cancer patients, resistance to the agent pre-exists or develops through the course of therapy. Here we show that a specific metabolism and autophagy-r...
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Article
Open AccessIncreased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer
The objective of this study was to determine the optimal scheduling of 2.5 mg daily letrozole in neoadjuvant breast cancer patients to obtain pathological complete response (pathCR) and assess Ki-67 expression...
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Article
Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
Junction-mediating and regulatory protein (JMY) is a novel p53 cofactor that regulates p53 activity during stress. JMY interacts with p300/CBP, which are ubiquitous transcriptional co-activators that interact ...
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Article
Regulation of autophagy by ATF4 in response to severe hypoxia
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cell...
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Article
An oncogenic role of eIF3e/INT6 in human breast cancer
Altered expression of the eukaryotic translation initiation factor 3 (eIF3) subunit eIF3e/INT6 has been described in various types of human cancer, but the nature of its involvement in tumorigenesis is not yet...
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Article
Open AccessChanges of bone turnover markers and serum PTH after night or morning administration of zoledronic acid in breast cancer patients with bone metastases
Persistent circadian rhythm of bone turnover in bone metastatic breast cancer suggests greater skeletal retention of bisphosphonates if administered in the night. We assessed differential effects of night vs morn...
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Article
Une « toxicité » sous-estimée : les impacts psychosociaux des traitements sur les proches aidants principaux
Dans le cadre d’une étude belge multicentrique, cet article rapporte l’évaluation qualitative et quantitative des besoins psychosociaux des proches aidants principaux des patients atteints d’un cancer, ainsi q...
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Article
Les besoins psychosociaux et le soutien apporté aux patients atteints d’un cancer: une étude nationale belge
Dans le cadre d’une étude Belge multicentrique, cet article rapporte l’évaluation qualitative et quantitative des besoins psychosociaux des patients atteints d’un cancer ainsi que les aides qu’ils souhaitent e...
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Article
Open AccessPaclitaxel, vinorelbine and 5-fluorouracil in breast cancer patients pretreated with adjuvant anthracyclines
We investigated the activity and toxicity of a combination of vinorelbine (VNB), paclitaxel (PTX) and 5-fluorouracil (5-FU) continuous infusion administered as first-line chemotherapy in metastatic breast canc...
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Article
The use of high energy laser-plasma sources in soft X-ray contact microscopy of living biological samples
In this paper the results of an experiment on soft X-ray contact microscopy using a laser-plasma source are presented. A resolution of 50 nm has been achieved imaging pig sperm cells, while other specimens, su...
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Chapter
Immunotherapy of Myasthenia Gravis
Myasthenia gravis (MG) is an acquired autoimmune disease of the neuromuscular junction mediated by antibodies against the nicotinic acetylcholine receptor (anti-AChR Ab). Anti-AChR Ab, by cross-linking AChR mo...
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Article
A critical analysis of radiation-matter interaction
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Chapter
Oral Administration of Peptide Tαl46-162 Prevents EAMG in Mice
Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction in which antibodies to the acetylcholine receptor (anti-AChR Ab) lead to muscle weakness and fatigability [1]. MG is treated with ...
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Article
NMR and pressure correlated analysis of metabolic changes in soft-X-rays irradiated yeast cells
An NMR technique for the identification of the energy related molecules, AMP, ADP and ATP, is suitably taylored to follow up the dynamics of the glycolitic metabolism in a suspension of yeast cells. Such a tec...
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Chapter
Frequency of Cardiovascular Risks Factor in Women Attending Menopause Clinics: Findings from the ICARUS Data Base
Coronary heart disease is generally considered a “man’s disease,” but it also the greatest killer of women older than 50 [1]. Cardiovascular diseases remain the main cause of morbidity and mortality in postmenopa...
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Article
Diabetes mellitus and peripheral vascular disease: is aspirin effective in preventing vascular events?
