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Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients
Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to...
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Article
Erratum to: Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells
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Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells
This study demonstrated the effects of the directionality of oscillatory wall shear stress (WSS) on proliferation and proatherogenic gene expression (I-CAM, E-Selectin, and IL-6) in the presence of inflammator...
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Article
Peristalsis with Oscillating Flow Resistance: A Mechanism for Periarterial Clearance of Amyloid Beta from the Brain
Alzheimer’s disease is characterized by accumulation of amyloid-β (Aβ) in the brain and in the walls of cerebral arteries. The focus of this work is on clearance of Aβ along artery walls, the failure of which may...
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Article
Apical-Ventricular Cannula for Aortic Valve Bypass Therapy
A growing number of elderly patients with significant co-morbidities do not meet the inclusion criteria for conventional cardiac surgical therapies, including aortic valve replacement and mechanical circulator...
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Simulated Stand Tests and Centrifuge Training to Prevent Orthostatic Intolerance on Earth, Moon, and Mars
One proposed method to overcome postflight orthostatic intolerance is for astronauts to undergo inflight centrifugation. Cardiovascular responses were compared between centrifuge and gravitational conditions u...
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Evaluation of Mechanisms of Postflight Orthostatic Intolerance with a Simple Cardiovascular System Model
A significant fraction of astronauts experience postflight orthostatic intolerance (POI) during 10-min stand tests conducted on landing day. The average time that nonfinishers can stand is about 7 min. This ph...
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Numerical Simulation of the Influence of Gravity and Posture on Cardiac Performance
A numerical model of the cardiovascular system was used to quantify the influences on cardiac function of intrathoracic pressure and intravascular and intraventricular hydrostatic pressure, which are fundament...
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Article
Influence of Gravity on Cardiac Performance
Results obtained by the investigators in ground-based experiments and in two parabolic flight series of tests aboard the NASA KC-135 aircraft with a hydraulic simulator of the human systemic circulation have c...
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Article
Scaling of Hemolysis in Needles and Catheters
Hemolysis in clinical blood samples leads to inaccurate assay results and often to the need for repeated blood draws. In vitro experiments were conducted to determine the influence on hemolysis in phlebotomy need...
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Article
Shear-augmented dispersion in non-Newtonian fluids
The rate of spread of a passive species is modified by the superposition of a velocity gradient on the concentration field. Taylor (18) solved for the rate of axial dispersion in fully developed steady Newtoni...