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14 Result(s)

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  1. No Access

    Article

    Deformation of human red blood cells in extensional flow through a hyperbolic contraction

    Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements o...

    Mohammad M. Faghih, M. Keith Sharp in Biomechanics and Modeling in Mechanobiology (2020)

  2. No Access

    Article

    Modeling and prediction of flow-induced hemolysis: a review

    Despite decades of research related to hemolysis, the accuracy of prediction algorithms for complex flows leaves much to be desired. Fundamental questions remain about how different types of fluid stresses tra...

    Mohammad M. Faghih, M. Keith Sharp in Biomechanics and Modeling in Mechanobiology (2019)

  3. No Access

    Article

    Characterization of erythrocyte membrane tension for hemolysis prediction in complex flows

    Hemolysis is a persistent issue with blood-contacting devices. Many experimental and theoretical contributions over the last few decades have increased insight into the mechanisms of hemolysis in both laminar ...

    Mohammad M. Faghih, M. Keith Sharp in Biomechanics and Modeling in Mechanobiology (2018)

  4. No Access

    Article

    Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients

    Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to...

    M. Keith Sharp, Mary Gregg, Guy Brock… in Cardiovascular Engineering and Technology (2017)

  5. Article

    Erratum to: Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells

    Amlan Chakraborty, Sutirtha Chakraborty… in Annals of Biomedical Engineering (2016)

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    Article

    Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells

    This study demonstrated the effects of the directionality of oscillatory wall shear stress (WSS) on proliferation and proatherogenic gene expression (I-CAM, E-Selectin, and IL-6) in the presence of inflammator...

    Amlan Chakraborty, Sutirtha Chakraborty… in Annals of Biomedical Engineering (2016)

  7. No Access

    Article

    Peristalsis with Oscillating Flow Resistance: A Mechanism for Periarterial Clearance of Amyloid Beta from the Brain

    Alzheimer’s disease is characterized by accumulation of amyloid-β (Aβ) in the brain and in the walls of cerebral arteries. The focus of this work is on clearance of Aβ along artery walls, the failure of which may...

    M. Keith Sharp, Alexandra K. Diem, Roy O. Weller… in Annals of Biomedical Engineering (2016)

  8. No Access

    Article

    Apical-Ventricular Cannula for Aortic Valve Bypass Therapy

    A growing number of elderly patients with significant co-morbidities do not meet the inclusion criteria for conventional cardiac surgical therapies, including aortic valve replacement and mechanical circulator...

    Kevin G. Soucy, Joel D. Graham… in Cardiovascular Engineering and Technology (2013)

  9. No Access

    Article

    Simulated Stand Tests and Centrifuge Training to Prevent Orthostatic Intolerance on Earth, Moon, and Mars

    One proposed method to overcome postflight orthostatic intolerance is for astronauts to undergo inflight centrifugation. Cardiovascular responses were compared between centrifuge and gravitational conditions u...

    Brandon W. Coats, M. Keith Sharp in Annals of Biomedical Engineering (2010)

  10. No Access

    Article

    Evaluation of Mechanisms of Postflight Orthostatic Intolerance with a Simple Cardiovascular System Model

    A significant fraction of astronauts experience postflight orthostatic intolerance (POI) during 10-min stand tests conducted on landing day. The average time that nonfinishers can stand is about 7 min. This ph...

    Justin Broskey, M. Keith Sharp in Annals of Biomedical Engineering (2007)

  11. No Access

    Article

    Numerical Simulation of the Influence of Gravity and Posture on Cardiac Performance

    A numerical model of the cardiovascular system was used to quantify the influences on cardiac function of intrathoracic pressure and intravascular and intraventricular hydrostatic pressure, which are fundament...

    Kristy Peterson, Edwin T. Ozawa, George M. Pantalos… in Annals of Biomedical Engineering (2002)

  12. No Access

    Article

    Influence of Gravity on Cardiac Performance

    Results obtained by the investigators in ground-based experiments and in two parabolic flight series of tests aboard the NASA KC-135 aircraft with a hydraulic simulator of the human systemic circulation have c...

    George M. Pantalos, M. Keith Sharp, Stewart J. Woodruff… in Annals of Biomedical Engineering (1998)

  13. No Access

    Article

    Scaling of Hemolysis in Needles and Catheters

    Hemolysis in clinical blood samples leads to inaccurate assay results and often to the need for repeated blood draws. In vitro experiments were conducted to determine the influence on hemolysis in phlebotomy need...

    M. Keith Sharp, S. Fazal Mohammad in Annals of Biomedical Engineering (1998)

  14. No Access

    Article

    Shear-augmented dispersion in non-Newtonian fluids

    The rate of spread of a passive species is modified by the superposition of a velocity gradient on the concentration field. Taylor (18) solved for the rate of axial dispersion in fully developed steady Newtoni...

    M. Keith Sharp in Annals of Biomedical Engineering (1993)