-
Article
What is the best surgical option after failure of graciloplasty in patients with recurrent rectovaginal fistula? A study of 19 consecutive patients
Management of recurrent rectovaginal fistula (rRVF) remains challenging despite the good results of graciloplasty reported in the literature. However, little is known about how to avoid a permanent stoma if gr...
-
Article
Mesorectal failure after chemoradiotherapy for squamous cell carcinoma of the anus: is sphincter-saving surgery reasonable?
Abdominoperineal resection (APR) is today the standard treatment for improving survival in case of mesorectal failure without anal canal recurrence after chemoradiotherapy (CRT) for squamous cell carcinoma of ...
-
Article
Open AccessWill our cardiomyopathy patients accept gene therapy?
Novel techniques such as gene therapy are becoming available in an attempt to cure inherited diseases. Before these new therapies can be offered to patients, we need to be aware of potential reservations or ob...
-
Article
C-reactive protein monitoring after ileocecal resection and stoma closure reduces length of hospital stay: a prospective case-matched study in 410 patients with Crohn’s disease
The aim of this study was to evaluate a C-reactive protein (CRP)-driven monitoring discharge strategy for patients with Crohn’s disease (CD) undergoing laparoscopic ileo-cecal resection (ICR) and if needed, te...
-
Article
Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I
Adeno-associated virus (AAV) -mediated gene therapy is a promising strategy to treat liver-based monogenic diseases. However, two major obstacles limit its success: first, vector dilution in actively dividing ...
-
Article
AAV9-mediated engineering of autotransplanted kidney of non-human primates
Ex vivo gene transfer to the graft before transplantation is an attractive option for circumventing systemic side effects of chronic antirejection therapy. Gene delivery of the immunomodulatory protein cytotoxic ...
-
Article
VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans
Tumor angiogenesis depends on the vascular endothelial growth factor (VEGF), which exists in multiple splicing isoforms, including the most abundant VEGF165 and VEGF121. We have previously shown that the differen...
-
Article
Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation
The Neuregulin/ErbB system plays an important role in the peripheral nervous system, under both normal and pathological conditions. We previously demonstrated that expression of soluble ecto-ErbB4, the release...
-
Article
Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: efficacy of class IV laser therapy
To retrospectively evaluate the role of class IV laser therapy in the amelioration of nutritional status of patients affected by oral mucositis due to radiotherapy of the head and neck region during oncologica...
-
Article
Open AccessEffect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy
Functional recovery after peripheral nerve injury depends on both improvement of nerve regeneration and prevention of denervation-related skeletal muscle atrophy. To reach these goals, in this study we overexp...
-
Article
VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond
Despite the enormous progress made in terms of prevention and early intervention, a pressing need remains to develop innovative therapeutic strategies for ischemic cardiovascular disorders, including acute myo...
-
Article
Erratum: Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
Correction to: Gene Therapy advance online publication, 12 May 2011; doi:10.1038/gt.2011.66 Since the online publication of this paper the authors have noticed that Figure 2 is incorrect. The Doppler data are ...
-
Article
Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
Vascular endothelial growth factor A (VEGF-A) induces strong angiogenesis and it has been widely used in proangiogenic gene therapy studies. However, little is known about long-term effects of VEGF-A expressio...
-
Article
Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse
We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-...
-
Article
Recombinant AAV vector encoding human VEGF165 enhances wound healing
Delivery of therapeutic genes represents an appealing possibility to accelerate healing of wounds that are otherwise difficult to treat, such as those in patients with metabolic disorders or infections. Experi...
-
Article
Variegation of retroviral vector gene expression in myeloid cells
We have comparatively evaluated the efficiency of a series of retroviral vectors transducing the gp91-phox gene, whose defects are responsible for impaired production of superoxide anion (O2−) by phagocytic cells...
-
Chapter and Conference Paper
Dilated Cardiomyopathy: Does Etiological Heterogeneity Portend Clinical Heterogeneity?
The etiology of dilated cardiomyopathy (DC), a disease of the myocardium characterized by dilatation and impaired contraction of the left ventricle or both ventricles, has been actively investigated for severa...
-
Article
Multivariate analysis of antibiograms for ty**Pseudomonas aeruginosa
A method for ty** Pseudomonas aeruginosa using antibiotic susceptibility patterns is presented, which allows recognition of clusters of t...
-
Article
Cluster analysis of antibiotic susceptibility patterns of clinical isolates as a tool in nosocomial infection surveillance
Hospital infections represent a major epidemiological problem. The first step in the detection of nosocomial infections consists in assessing the probability that two or more isolates from different patients a...
