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Article
The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer
To investigate the possibility of using the methylation level of PAX1/ZNF582 gene as molecular marker to differentiate the progression of cervical cancer.
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Article
Long-term application potential of urban air mobility complementing public transport: an upper Bavaria example
In this paper, the required models and methods to analyze and quantify the potential demand for urban air mobility (UAM) complementing public transport and possible impacts were defined and applied to the Muni...
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Article
Correction to: Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats
There was a mistake in the part of OVX rats model and RRP intervention in the original publication.
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Article
Characterization of the first prototype CMOS pixel sensor developed for the CEPC vertex detector
CMOS pixel sensor has become extremely attractive for future high-performance tracking devices. It has been proposed for the vertex detector at the Circular Electron Positron Collider, which will allow precisi...
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Article
Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats
Rehmanniae Radix Preparata (RRP) improves bone quality in OVX rats through the regulation of bone homeostasis via increasing osteoblastogenesis and decreasing osteoclastogenesis, suggesting it has a potential for...
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Article
Open AccessAdherence to optimal heart rate control in heart failure with reduced ejection fraction: insight from a survey of heart rate in heart failure in Sweden (HR-HF study)
Despite that heart rate (HR) control is one of the guideline-recommended treatment goals for heart failure (HF) patients, implementation has been painstakingly slow. Therefore, it would be important to identif...
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Article
Open AccessFactors associated with implementation of the 5A’s smoking cessation model
Several health organizations have adopted the 5A’s brief intervention model (Ask, Advise, Assess, Assist, Arrange), based on evidence-based guidelines for smoking cessation. We examine individual, cognitive, b...
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Article
Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma
The presynaptic cytomatrix protein Piccolo, encoded by PCLO, is frequently mutated and amplified in esophageal squamous cell carcinoma (ESCC), but its exact roles in ESCC remain unclear. Here we report that Picco...
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Article
Evolution of the Piezomagnetic Field of Ferromagnetic Steels Subjected to Cyclic Tensile Stress with Variable Amplitudes
In this research, the evolutions of the piezomagnetic fields of ferromagnetic steels under cyclic tensile stress with variable amplitudes were investigated. The piezomagnetic signals of initially undemagnetize...
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Article
Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide and occurs at a relatively high frequency in China, yet the mechanisms underlying its devastating outcome remain uncle...
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Article
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL
The functional relevance of the B-cell receptor (BCR) and the evolution of protein kinases as therapeutic targets have recently shifted the paradigm for treatment of B-cell malignancies. Inhibition of p110δ wi...
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Article
Open AccessEMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF
Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define a novel function for epithelial membrane protei...
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Article
Glucose metabolism among residents in Shanghai: Natural outcome of a 5-year follow-up study
Background: Previous studies have shown that Type 2 diabetes mellitus (T2DM) is usually preceded by a condition known as pre-diabetes. However, few studies evaluate the rate of each status of imp...
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Article
Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release
Autocrine motility factor/ phosphoglucose isomerase (AMF/PGI) promotes cell survival by the pAkt survival pathway. Its receptor, gp78/AMFR, is an E3 ubiquitin ligase implicated in endoplasmic reticulum (ER)-as...
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Article
Rapid Thermal Processing of Implanted GaN Up to 1500°C
GaN implanted with donor(Si, S, Se, Te) or acceptor (Be, Mg, C) species was annealed at 900-1500°C using AIN encapsulation. No redistribution was measured by SIMS for any of the dopants and effective diffusion...
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Article
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway
xCT, the functional subunit of the cystine/glutamate transporter xc- system, plays a critical role in the maintenance of intracellular glutathione and redox balance. Disruption of xCT significantly inhibits th...
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Article
A polysaccharide–peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice
The antioxidant effects of a polysaccharide–peptide complex (F22) from mushroom (Pleurotus abalonus)-fruiting bodies were studied. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione per...
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Article
Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study
In this study, we performed a detailed topographical study on the development of ganglion plexuses and the smooth muscle layers of human embryonic and fetal gut. Neuron and glia differentiation was investigate...
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Article
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARγ-independent pathway in human aortic smooth muscle cells
Inhibitor of DNA binding (Id2) is a member of the helix-loop-helix family of transcription regulators that is known to play important roles in the proliferation and differentiation of many cell types. Overexp...
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Article
Rapid Thermal Processing of Implanted GaN up to 1500°C
GaN implanted with donor(Si, S, Se, Te) or acceptor (Be, Mg, C) species was annealed at 900-1500 °C using AlN encapsulation. No redistribution was measured by SIMS for any of the dopants and effective diffusio...
