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Correction to: Osteoporos Int.
There was a mistake in the part of OVX rats model and RRP intervention in the original publication. The dosage of EV (0.1 mg/1 mL/100 g) and RRP (2.5 g/1 mL/100 g) should be corrected as EV (0.01 mg/1 mL/100 g) and RRP (0.25 g/1 mL/100 g).
In addition, the names and serial numbers of compounds in Supplement Fig. 1 were unfortunately incorrect. The figure is reproduced here.
Moreover, the authors carelessly uploaded the wrong images (Fig. 6a) for the Sham Group and OVX Group. The figure below shows the correct images. The error does not affect the interpretation and conclusion of the study. The authors apologize for any inconvenience that this error may have caused.
Fig. 6Rehmanniae Radix Preparata (RRP) improves IGF-1 expression in the femurs and potential mechanism of RRP prevents the development of osteoporosis in OVX rats. The representative micro-images (a) and their analyses (b) of immunohistochemical staining (sections were counterstained with hematoxylin; original magnification, × 200 and × 400) show the IGF-1 expression in the rat femurs of the treatment and control groups. Data are presented as mean ± SD. The dark brown particles denote positive staining. IOD denotes integrated optical density of interested areas. #p < 0.05 compared with Sham group, *p < 0.05 compared with OVX group. n = 9. (c) The potential mechanism of Rehmanniae Radix Preparata (RRP) against osteoporosis in OVX rats. RRP may downregulate overexpression of DKK1 and sclerostin as well as increase IGF-1 expression, which further activates the Wnt/β-catenin signaling pathway and contributes to subsequent bone formation. RRP may also increase OPG expression and secretion, which leads to an inhibition of the RANKL/cathepsin K-mediated bone resorption. In addition, the increased expression of β-catenin further activates OPG/RANKL signaling. The sign (↓) means promoting. The sign (┴) means inhibiting. CTSK, cathepsin K; DKK1, Dickkopf-related protein-1; GSK-3β, glycogen synthase kinase 3β; IGF-1, insulin-like growth factor-1; OPG, osteoprotegerin; RANKL, receptor activator for nuclear factor-κB ligand
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The online version of the original article can be found at https://doi.org/10.1007/s00198-018-4670-y
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Liu, C., Wang, L., Zhu, R. et al. Correction to: Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats. Osteoporos Int 30, 1537–1540 (2019). https://doi.org/10.1007/s00198-019-05028-0
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DOI: https://doi.org/10.1007/s00198-019-05028-0