5 Result(s)
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M. Christiane Brahimi-Horn
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Article
Open AccessKnockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental con...
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Chapter and Conference Paper
Hypoxic VDAC1: A Potential Mitochondrial Marker for Cancer Therapy
Finding new therapeutic targets to fight cancer is an ongoing quest. Because of insufficiencies in tumor vasculature, cells often are exposed to a hostile microenvironment that is low in oxygen (hypoxic) and n...
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Article
Open AccessA Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment
The hypoxia-inducible factor is the key protein responsible for the cellular adaptation to low oxygen tension. This transcription factor becomes activated as a result of a drop in the partial pressure of oxyge...
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Chapter
Hypoxia and Tumour Angiogenesis
The hypoxia-inducible factor (HIF) is a well-known transcription factor recognized to play a key role in tumour angiogenesis through a cellular response to a low tissue oxygen concentration, a feature of a rap...
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Article
Hypoxia and cancer
A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissue...
