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  1. No Access

    Article

    Limited sampling strategy and population pharmacokinetic model of mycophenolic acid in pediatric patients with systemic lupus erythematosus: application of a double gamma absorption model with SAEM algorithm

    Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is widely used in the treatment of systemic lupus erythematosus (SLE). It has been shown that its therapeutic drug monitoring base...

    Kévin Koloskoff, Sylvain Benito, Lucie Chambon… in European Journal of Clinical Pharmacology (2024)

  2. No Access

    Chapter

    Modeling and Analysis of Gene Regulatory Networks

    This chapter describes basic principles for modeling genetic regulatory networks, using three different classes of formalisms: discrete, hybrid, and continuous differential systems. A short review of the mathe...

    Gilles Bernot, Jean-Paul Comet… in Modeling in Computational Biology and Biom… (2013)

  3. Article

    Open Access

    A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment

    The hypoxia-inducible factor is the key protein responsible for the cellular adaptation to low oxygen tension. This transcription factor becomes activated as a result of a drop in the partial pressure of oxyge...

    Frédéric Dayan, Nathalie M. Mazure, M. Christiane Brahimi-Horn… in Cancer Microenvironment (2008)

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  4. No Access

    Article

    Hypoxia signalling in cancer and approaches to enforce tumour regression

    Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling ne...

    Jacques Pouysségur, Frédéric Dayan, Nathalie M. Mazure in Nature (2006)