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Article
Open AccessA MYC-rearrangement is a negative prognostic factor in stage II, but not in stage I diffuse large B-cell lymphoma
MYC oncogene rearrangements (MYC-R) negatively affect survival in patients with Ann Arbor stage III–IV diffuse large B-cell lymphoma (DLBCL), but their impact in limited stage (LS) I–II is unclear. Therefore, we ...
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Article
Open AccessEffects of surface treatments on flux tunable transmon qubits
One of the main limitations in state-of-the art solid-state quantum processors is qubit decoherence and relaxation due to noise from adsorbates on surfaces, impurities at interfaces, and material defects. For ...
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Article
Population-based analyses among 184 patients diagnosed with large granular lymphocyte leukemia in the Netherlands between 2001 and 2013
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Article
Secundaire maligniteiten bij patiënten met een seminoma testis stadium I behandeld met adjuvante radiotherapie
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Article
Open AccessInfluence of routine computed tomography on predicted survival from blunt thoracoabdominal trauma
Many scoring systems have been proposed to predict the survival of trauma patients. This study was performed to evaluate the influence of routine thoracoabdominal computed tomography (CT) on the predicted surv...
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Article
Determining physiological reaction probabilities to noise events during sleep
Some of the activations that occur during sleep, e.g. awakening reactions, can be considered adverse effects of noise events (e.g., airplane overflights or train passings) during the night. The occurrence of s...
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Article
Influence of slope of rise and event order of aircraft noise events on high resolution actimetry parameters
Starts und Landungen in der Nacht sind bei den meisten Verkehrsflughäfen durch eine Nachtflugsperre eingeschränkt. Die Empfindlichkeit der Bevölkerung, durch Fluglärm im Schlaf gestört zu werden, ist daher zu ...
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Article
Telephone consultation in palliative care for cancer patients: 5 years of experience in The Netherlands
To analyze cancer patient-related consultations of a telephone helpdesk (TH) for palliative care over a period of 5 years in the region of Utrecht, The Netherlands.
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Article
Open AccessMeat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
Case–cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and ...
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Article
Dose-dependent effect of angiotensin II on human erythropoietin production
Current evidence suggests that angiotensin II may be involved in the regulation of renal erythropoietin (EPO) production. The present study assessed the role of angiotensin II (A II) in different doses in the ...
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Chapter and Conference Paper
Interactions Between Wingless and Frizzled Molecules in Drosophila
Over the past decade, our understanding of the mechanisms underlying growth and patterning of tissues has been enormously increased due to a convergence of the fields of developmental genetics and cancer resea...
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Article
Expression of chromogranin A and B and secretoneurin immunoreactivity in neoplastic and nonneoplastic pancreatic alpha cells
In the endocrine pancreas, chromogranins A and B as well as secretoneurin (a biologically active peptide processed endoproteolytically from secretogranin II) are most intensely expressed in alpha (glucagon) ce...
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Article
Down syndrome and coeliac disease: five new cases with a review of the literature
We report five new patients with coeliac disease and Down syndrome and review the 11 cases previously reported in the literature. In 14 of these 16 patients diarrhoea was the presenting symptom and in 2 failur...
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Article
Combined deficiency of xanthine oxidase and sulphite oxidase: A defect of molybdenum metabolism or transport?
A child is described who presented in the neonatal period with feeding difficulties, severe neurological abnormalities, lens dislocation of the eyes and dysmorphic symptoms of the head. Routine laboratory inve...
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Article
Attempted dietary treatment of a boy with hyperammonemia due to ornithine transferase deficiency
Dietary treatment of a male patient suffering from the delayed-onset type of OCT deficiency was attempted. Control of the hyperammonemia was attempted by restriction of protein intake, guided by monitoring the...
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Article
Familial hyperlysinaemia due to L-lysineα-ketoglutarate reductase deficiency: Results of attempted treatment
A mentally retarded male infant with persistent hyperlysinaemia due to L-lysineα-ketoglutarate reductase deficiency is described. The effect of dietary restriction of lysine on his mental and behavioural developm...
