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  1. No Access

    Protocol

    Generation and Evaluation of Bispecific Anti-TNF Antibodies Based on Single-Chain VHH Domains

    Systemic cytokine inhibition may be an effective therapeutic strategy for several autoimmune diseases. However, recent studies suggest that tissue or cell type–specific targeting of certain cytokines, includin...

    M. A. Nosenko, K. -S. N. Atretkhany, V. V. Mokhonov, S. A. Chuvpilo… in The TNF Superfamily (2021)

  2. No Access

    Article

    Proinflammatory Cytokines and Skin Wound Healing in Mice

    Skin wound healing is subject to an intricate regulation, involves many cell populations and molecular mediators, and is one of the key mechanisms that ensures the barrier functions of the skin and the mainten...

    M. A. Nosenko, S. G. Ambaryan, M. S. Drutskaya in Molecular Biology (2019)

  3. No Access

    Article

    Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells

    To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in cells of macrophage-monocyte lineage were generated u...

    R. V. Zvartsev, D. S. Korshunova, E. A. Gorshkova… in Doklady Biochemistry and Biophysics (2018)

  4. No Access

    Article

    Proinflammatory and Immunoregulatory Functions of Interleukin 6 as Identified by Reverse Genetics

    Reverse genetics approach, involving genome editing, makes it possible not only to establish the nonredundant and unique functions of genes and their products, but also to construct animal models for biomedica...

    M. S. Drutskaya, V. S. Gogoleva, K.-S. N. Atretkhany… in Molecular Biology (2018)

  5. No Access

    Article

    Effects of fibroin microcarriers on inflammation and regeneration of deep skin wounds in mice

    The process of tissue regeneration following damage takes place with direct participation of the immune system. The use of biomaterials as scaffolds to facilitate healing of skin wounds is a new and interestin...

    A. Y. Arkhipova, M. A. Nosenko, N. V. Malyuchenko, R. V. Zvartsev… in Biochemistry (Moscow) (2016)

  6. No Access

    Article

    Interleukin-6: From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting

    Interleukin-6 (IL-6) is one of the most important proinflammatory cytokines that has a broad spectrum of immunoregulatory properties. The molecular mechanisms of signal transduction of IL-6 and its receptor, w...

    M. S. Drutskaya, M. A. Nosenko, K.-S. N. Atretkhany, G. A. Efimov… in Molecular Biology (2015)

  7. No Access

    Article

    Influence of the thermal action of artificially-initiated lightning current on specimens of the metal skin of an aircraft

    This paper presents the results of investigations of the thermal action on sheet specimens of the skin of an aircraft from aluminum alloy AMn with a wall thickness from 2 to 6 mm of the pulse A-component (with a ...

    M. I. Baranov, M. A. Nosenko in Journal of Engineering Physics and Thermophysics (2009)

  8. No Access

    Article

    High-voltage high-current air-filled spark gaps of an artificial-lightning-current generator

    The designs of two high-voltage high-current air-filled spark gaps of an artificial-lightning-current generator-a two-electrode ДMBP-5 gap for a voltage of up to ±5 kV with graphitized-carbon electrodes and a ...

    M. I. Baranov, G. M. Koliushko, V. I. Kravchenko… in Instruments and Experimental Techniques (2008)