920 Result(s)
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Article
Effects of antipsychotic drugs on energy metabolism
Schizophrenia (SCZ) is a complex neuropsychiatric disorder associated with altered bioenergetic pathways and mitochondrial dysfunction. Antipsychotic medications, both first and second-generation, are commonly...
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Article
Open AccessA bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has previously been associated with bipolar disorder (BD). Here we ...
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Article
Open AccessIdentification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring their connection with disease status. Retinal cross-sections f...
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Article
DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism
Cancer patients are commonly affected by fatigue. Herein, we sought to examine epigenetic modifications (i.e., DNA methylation) related to fatigue in peripheral blood among patients during and after treatment ...
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Open AccessInfluenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Epidemiological studies link exposure to viral infection during pregnancy, including influenza A virus (IAV) infection, with increased incidence of neurodevelopmental disorders (NDDs) in offspring. Models of m...
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Article
Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech
Nonfluent variant primary progressive aphasia (nfvPPA) and primary progressive apraxia of speech (PPAOS) can be precursors to corticobasal syndrome (CBS). Details on their progression remain unclear. We aimed ...
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Article
Frontal hypometabolism in the diagnosis of progressive supranuclear palsy clinical variants
Frontal hypometabolism on FDG-PET is observed in progressive supranuclear palsy (PSP), although it is unclear whether it is a feature of all PSP clinical variants and hence whether it is a useful diagnostic fe...
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Open AccessAlzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development
Alzheimer’s disease (AD) is a complex multifaceted disease. Recently approved anti-amyloid monoclonal antibodies slow disease progression by approximately 30%, and combination therapy appears necessary to prev...
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Article
Open AccessFunctional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods
Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought to (Objective I) define the main functional phenotypes in SSD, then (Objective II) identify key biops...
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Article
Open AccessThe single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...
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Article
Endovascular thrombectomy with versus without intravenous thrombolysis in patients with acute basilar artery occlusion: a systematic review and meta-analysis
The benefit and safety of intravenous thrombolysis before endovascular thrombectomy in patients with acute ischemic stroke caused by basilar artery occlusion (BAO) remains unclear. This article aims to investi...
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Open AccessOxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame
Prosocial and moral behaviors have overlap** neural systems and can both be affected in a number of psychiatric disorders, although whether they involve similar neurochemical systems is unclear. In the curre...
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Article
Open AccessReduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders
A hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that reduction of Apolipoprotein E (APOE) is critically involved i...
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Open AccessMonozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in mono...
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Open AccessBrain and blood transcriptome profiles delineate common genetic pathways across suicidal ideation and suicide
Human genetic studies indicate that suicidal ideation and behavior are both heritable. Most studies have examined associations between aberrant gene expression and suicide behavior, but behavior risk is linked...
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Systematic review and cumulative analysis of clinical properties of BRAF V600E mutations in PLNTY histological samples
Polymorphous low-grade neuroepithelial tumors of the young (PLNTY) represent a rare pediatric-type tumor that most commonly presents as medically refractory epilepsy. PLNTY has only recently been recognized as...
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Open AccessNetwork-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as it leverages the wealth of expanding biomedical databases. ...
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Article
Open AccessDNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the cont...
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Article
Open AccessSystematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders
Deep brain stimulation (DBS) modulates local and widespread connectivity in dysfunctional networks. Positive results are observed in several patient populations; however, the precise mechanisms underlying trea...
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Open AccessWhite matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predo...
