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Article
DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism
Cancer patients are commonly affected by fatigue. Herein, we sought to examine epigenetic modifications (i.e., DNA methylation) related to fatigue in peripheral blood among patients during and after treatment ...
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Article
Open AccessLongitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC
In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerat...
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Article
Open AccessClonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition...
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Article
Open AccessDNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1...
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Article
Open AccessDifferential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA met...
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Article
Open AccessGenome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation i...
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Article
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Recent evidence supports a key role of gut microbiome in brain health. We conducted a pilot study to assess associations of gut microbiome with cancer-related fatigue and explore the associations with DNA meth...
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Open AccessTen-eleven translocation protein 1 modulates medulloblastoma progression
Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and deregulated expression of epigenetic regulators in MB hig...
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Article
Open AccessAssociation between DNA methylation levels in brain tissue and late-life depression in community-based participants
Major depressive disorder (MDD) arises from a combination of genetic and environmental risk factors and DNA methylation is one of the molecular mechanisms through which these factors can manifest. However, lit...
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Article
Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis
Endocrine disrupting compounds (EDCs) have been shown to affect multiple biologic processes especially steroid-hormone processes. We sought to determine differences in DNA methylation exists between women with...
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Open AccessGenome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-associated variants from genome-wide association studies (GWAS) may illuminate functional mechanisms underlying geneti...
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Article
Open AccessThyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children
Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB). A growing body of evidence suggests that exposure to certain endocr...
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Article
Robust Rare-Variant Association Tests for Quantitative Traits in General Pedigrees
Next-generation sequencing technology has propelled the development of statistical methods to identify rare polygenetic variation associated with complex traits. The majority of these statistical methods are d...
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Open AccessAn integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
Gene expression can be influenced by DNA methylation 1) distally, at regulatory elements such as enhancers, as well as 2) proximally, at promoters. Our current understanding of the influence of distal DNA meth...
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Article
A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk
DNA methylation (DNAm) has been found to show robust and widespread age-related changes across the genome. DNAm profiles from whole blood can be used to predict human aging rates with great accuracy. We sought...
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Open AccessDNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inf...
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Open AccessAn epigenetic clock for gestational age at birth based on blood methylation data
Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately esti...
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Article
Statistical Challenges in Analyzing Methylation and Long-Range Chromosomal Interaction Data
With the rapid development of high-throughput technologies such as array and next generation sequencing, genome-wide, nucleotide-resolution epigenomic data are increasingly available. In recent years, there ha...
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Article
Open AccessThe transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression met...
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Testing evolutionary models of senescence: traditional approaches and future directions
From an evolutionary perspective, the existence of senescence is a paradox. Why has senescence not been more effectively selected against given its associated decreases in Darwinian fitness? Why does senescenc...
